H2020Индивидуална стипендия2019–2021

PHAS · Development of a new generation of bioengineered bandages

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2019-05-01 → 2021-04-30
Финансиране от ЕС: 191 149 €
Участници: 1
Схема: MSCA-IF-EF-SE

Линиите свързват координатора с партньорите.

Накратко на български

Биоинженерни превръзки с антимикробни вещества и биополимери се тестват за по-бързо възстановяване на кожата при изгаряния. Това е важно, защото инфекциите при тежките рани често са устойчиви на антибиотици и повишават риска от смърт.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Development of a new generation of bioengineered bandages

According to the World Health Organization, burn injuries implicate over 260,000 deaths each year and 11 million hospital consultations. Thus, burns remain among the common causes of trauma and death worldwide. Care management has improved over the last decade so that survival from the initial trauma has enhanced. However, subsequent infections due to exposed areas, have become a leading cause of morbidity and particularly in the case of severe skin damage. Furthermore, the rate of mortality in burn patients is three times higher in patients that are infected by pathogens. Such infections are particularly worrisome in the context of an increasing rise in the resistance of bacterial pathogens to antibiotic treatments, as resistance is among the top ten cause of death, implying an urgent need for the development of novel therapies. With the support of the Marie Skłodowska-Curie program, the objective of the PHAS project was to improve patient healing, which in turn would reduce hospitalization duration and costs. Specifically, we investigated several formulations for developing a bioactive skin bandage which could cope with the burden of infections and enhance wound repair. In parallel, we implemented metagenomics techniques to identify the communities of microorganisms which may favor the advent of cutaneous infections. In the frame of this action, promising antimicrobial candidates were identified and tested, showing good biocompatible properties for topical release, which could be used as alternative to antibiotics or Silver ions. Likewise, several formulations of bio-polymers were assessed and showed good biocompatible properties also, having thus the potential to be used as novel types of scaffolds to be combined with progenitor cells and our tested antimicrobials to form a novel anti-infective bio-bandage favoring the healing of burn wounds. The results generated in the frame of this action (TRL3) will be used for future investigations, to advance the technology formulated in the lab towards demonstration in a relevant environment (TRL5), i.e. in-vivo testing. The associated tissue engineering products to be further developed have the potential to affect many stakeholders, covering academic and business interests, physicians, and last but not least, the burn patients.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Skin wounds are of major causes for global disease burden, affecting millions of people worldwide. Furthermore, over half of skin wounds become infected, which is a major limiting factor for recovery, especially after severe burns. Indeed, because of modern resuscitation procedures, burn patients usually survive the initial trauma and it is the burn wound infection that remains the major cause of mortality and healing delay. This is particularly true for severely burned patients for whom immediate wound closure is not possible, leaving them for very long periods of time non-grafted. Treatment is associated with prolonged hospitalizations and significant costs, without mentioning the severe pain, emotional and physical strain that the burn trauma inflicts to the individual affected. We propose here to develop a novel bioactive skin substitute to cope with the burden of infections, and thus align with the World Health Organization’s strategic plan for effective and sustainable burn prevention and care policies. As the ultimate aim is to translate the novel approach in regenerative medicine from bench-side to bedside, I will engage in the frame of this action a synergistic endeavor with several actors of their respective field, to boost the research and meet the imposed regulatory requirements for the introduction of new treatments into clinics, as well as to use cutting-edge techniques such as metagenomics and MALDI-TOF to determine the temporal diversity and evolution of microbial communities for various burn patient cohorts.

Оригинален текст от CORDIS (на английски).

Участници

CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS · LausanneКоординаторШвейцария