H2020Индивидуална стипендия2020–2022

PolyBiota · Polyphenols and Gut Microbiota interaction in Cardiovascular Health

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2020-07-16 → 2022-11-04
Финансиране от ЕС: 172 932 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Полифенолите от растителните храни и тяхното взаимодействие с бактериите в червата влияят върху сърдечно-съдовото здраве. Разбирането на тази връзка помага за създаването на индивидуални диети за предпазване от хронични заболявания.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Polyphenols and Gut Microbiota interaction in Cardiovascular Health

An important number of European Public Health Programmes have considered diet (and, in turn, the consumption of plant-derived foodstuff) as one of the cornerstones in the prevention/treatment of cardiovascular diseases (CVDs). In this regard, (Poly)phenols (constituents of plant foods) have been in the spotlight of food scientists´ investigations as the molecules responsible for the benefits (i.e., anticancer and/or anti-inflammatory effects) associated with vegetables consumption. However, the different responses to (poly)phenols consumption depending on the individual, make it difficult to unequivocally correlate (poly)phenols intake and human health. This is the critical issue the PolyBiota project is intended to improve upon, thus contributing to establish proper diets based on individuals’ features (such as the gut microbiota) as strategy towards the prevention of chronic diseases. The underlying premise of PolyBiota invokes the gut microbiota (individual´s fingerprint) as a key element to shed some light to the role of (poly)phenols on human health. The preliminary results from this investigation showed interesting and potentially ground-breaking outcomes. The consumption of a diet enriched with vegetables or (poly)phenols modulated the inflammatory response in animal models, while this effect was less evident when the gut microbiota was imbalanced. Besides, the study of the effects of (poly)phenols in relevant cellular models, under conditions similar to those described in vivo, described the capacity of these molecules to modulate processes linked to angiogenesis. These results highlight the role of the gut microbiota in modulating the role of (poly)phenols, and how both could act in tandem to exert beneficial effects at the cardiovascular level.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Cardiovascular disease (CVD) is the main cause of mortality in Europe with an annual estimated cost of €210 billion. Different European Public Health strategies have targeted diet to prevent/treat CVDs. This multidisciplinary and multi-institutional project aims to provide new insights into the role of the gut microbiota as a key player in the beneficial effects against CVDs associated with the consumption of Polyphenols (PPs)-rich foods. PolyBiota will be developed through innovative research at one of the epicenters of PPs research (CEBAS-CSIC) and secondment at FISABIO (Valencia, Spain). Epidemiological, clinical, and preclinical studies suggest that the consumption of PPs-containing food protects against CVDs (i.e, modulating angiogenesis in atherosclerotic plaques) . However, these benefits are not always observed due to the high inter-individual variability. The gut microbiota has emerged as an essential player that regulates the bioactivity of PPs. Recent clinical trials indicate that the gut microbiota composition play a critical role in the activity of PPs improving CV biomarkers. These studies open a new door to investigate how the interaction PPs-gut microbiota can modulate mechanisms associated with the improvement of CVDs. PolyBiota will investigate: i) role of the gut microbiota as mediator of the effects of the consumption of Ellagitannins (ETs)-/urolithin (Uro)-A- and Isoflavones (IsoFlv)-/equol-enriched diets on angiogenesis/mechanisms related in untreated and antibiotic-treated animals, ii) the “prebiotic-like effect” of the ETs, Uro-A, IsoFlv and equol consumption on the gut microbiota population, iii) the effects of the gut microbiota-biosynthesized messenguers or the ETs- and IsoFlv-derived metabolites on in vitro tubulogenesis. PolyBiota shows an innovative approach combining cutting-edge techniques, “big data” management, endothelial cells, and in vivo animal models providing a holistic scene of the Diet-Gut Microbiota-Host interaction.

Оригинален текст от CORDIS (на английски).

Участници

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS · MadridКоординаторИспания