H2020Индивидуална стипендия2019–2021

SNFWD · A pH-Responsive Bionanohybrid Nanofibrous Wound Dressing

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2019-08-01 → 2021-07-31
Финансиране от ЕС: 162 806 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Нанофибърни превръзки, които реагират на pH нивото на раната, се разработват чрез биоминерализация за контролирано освобождаване на лекарства. Те могат да подобрят заздравяването на хронични рани, като диабетичните улцери, и да намалят броя на ампутациите на крайниците.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

A pH-Responsive Bionanohybrid Nanofibrous Wound Dressing

Importance for Society: Globally, chronic wounds e.g. diabetic ulcers impose a notable burden to patients and the health systems. In Europe, there are more than 55 million patients suffering from diabetes, thereof 8 million patients are vulnerable to developing a diabetic foot ulcer. As a consequence of inefficient treatment of such ulcers, up to 450,000 lower limb amputations take place that can cost as much as €2–2.5 billion. Yet, appropriate treatment strategies including use of wound dressings with high healing rate can prevent the undesired outcomes and alleviate such costs. The targeted problem: To address the dynamic nature of wound healing, the wound care market is transitioning from classic protective barriers into advanced, active wound dressings, interacting with the wound by stimulating and managing cell migration and the sequence of healing events. In this regard, development of smart drug delivery wound dressings based on nanofibers, is a novel topic that could be of high importance due to the biomimicry and high surface area of such materials bringing about better dissolution rate and ease of incorporation of drugs. However, to industrially realize such systems, there are still some challenges. Of the most important challenges is fabrication approach of such systems, that must not lead to either a burst release or damage to the drug during the process. Overall objectives: In this project, I dealt with this challenge and proposed a novel approach based on biomineralization for smart delivery of drug by a nanofibrous wound dressing. In this biomineralized nanofiber wound dressing, not only the nanofibrous structure and its biomimetic formulation and smart drug delivery facilitates interaction with live cells and manages the healing process, respectively, but also cheap and fast electrospinning process promise an industrially adaptable approach. Thus, this proposed research would be an important novel step towards introduction of nanofibrous drug delivery wound dressings to industry.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

To address the dynamic nature of wound healing, the wound care market is transitioning from classic protective barriers into advanced, active wound dressings, interacting with the wound by stimulating and managing cell migration and the sequence of healing events. In this regard, development of smart drug delivery wound dressings based on nanofibers, is a novel topic and of high importance due to the porosity, biomimicry and high surface area of such materials bringing about very optimum oxygen and water permeability, enhanced cell activity thus healing rate and better dissolution rate and ease of incorporation of drugs, respectively. However, to industrially realize such systems, there are still some challenges. Of the most important challenges is fabrication approach of such systems, that must not lead to either a burst release or damage to the drug during the process. As a novel idea, I aim to biomineralize a doped calcium phosphate drug carrier coating on the surface of nanofibers that could be efficiently loaded by drug molecules through electrostatic interactions. To accelerate the healing rate of chronic wounds, the wound medium is conventionally acidified by topical application of acids. This synthetic acidification along with natural trend of acidification of the wound as far as healing continues, can lead to dissolution of the drug carrier coating, thus release of drug molecules in a controlled manner. In this nanofibrous wound dressing, not only the nanofibrous structure biomimicking natural extracellular matrix of human tissues and smart drug delivery facilitates interaction with live cells and manages the healing process, respectively, but also cheap and fast electrospinning process for production of nanofibers promise an industrially adaptable approach. Thus, this proposed research would be an important novel step towards introduction of nanofibrous drug delivery wound dressings to industry.

Оригинален текст от CORDIS (на английски).

Участници

FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG · ErlangenКоординаторГермания