HYMNS · Hypothalamic Modulation of Neocortical States
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2021-01-01 → 2024-07-29
- Финансиране от ЕС
- 278 841 €
- Участници
- 3
- Схема
- MSCA-IF
Линиите свързват координатора с партньорите.
Накратко на български
Хистаминът в мозъка влияе върху невронната активност и ритмите, които управляват вниманието и паметта. Разбирането на тези механизми помага при работата с неврологични разстройства като болестите Алцхаймер, Паркинсон и шизофренията.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Hypothalamic Modulation of Neocortical States
The neocortex is extensively regulated by neuromodulatory systems that release neurotransmitters, neuropeptides, and hormones to shape neuronal excitability and synaptic transmission. Key neuromodulators—including histamine (HA), acetylcholine, noradrenaline, dopamine, and serotonin—originate from subcortical nuclei and fine-tune cortical activity, playing essential roles in cognition and behavior. These systems regulate transitions between cognitive states by influencing cortical oscillations, such as gamma rhythms (30–80 Hz), which are crucial for attention, learning, and memory. Histamine, released by tuberomammillary nucleus (TMN) neurons, modulates cortical states and rhythmic network activity, with elevated HA levels correlating with gamma oscillations and cognitive function, though its precise mechanisms remain unclear. Dysregulated HA signaling is linked to neurological disorders like Alzheimer’s, Parkinson’s, and schizophrenia, contributing to cognitive deficits and disrupted neural dynamics. Given the €200 billion annual cost of neurodegenerative diseases in Europe, understanding HA’s role in neocortical circuits has significant therapeutic potential. HYMNS aims to systematically decode HA’s influence on cortical function, providing insights for both fundamental neuroscience and translational research.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
The neocortex is densely innervated by neuromodulatory systems that act through the release of hormones, neuropeptides, and neurotransmitters such as histamine (HA), acetylcholine (ACh), noradrenaline (NA), dopamine (DA), and serotonin (5-HT), which modulate cortical function by diffusely targeting neurons and synapses in neural microcircuits. These neuromodulators regulate shifts between behavioral states such as sleep and wakefulness, or distraction and attention by controlling rhythmic network activity. It is thought that neuromodulators regulate rhythmic activity by controlling the intrinsic characteristics of neuronal networks across different organizational levels – dendritic properties, cellular physiology, synaptic plasticity, and microcircuit dynamics. Recent work has demonstrated that high-frequency “gamma” oscillations (30-80 Hz), which crucially subserve cognitive processes such as attention, learning and memory, are associated with an increase in HA levels in subcortical regions. Altered levels of HA in the neocortex and dysfunction of its receptors have been implicated in the onset of Alzheimer’s and Parkinson’s disease – pathologies whose economic cost to Europe has been estimated at about € 200 billion per year. Despite the importance of HA in brain function and dysfunction, the mechanisms through which it controls neuronal, synaptic, dendritic, and microcircuit activity in the neocortex are unknown. Therefore, the objective of the HYMNS project is to employ an innovative combination of experiments and computational modelling to provide a unifying view of the mechanisms by which HA enables rhythmic microcircuit activity by controlling different organizational levels in the neocortex. The novel methods established in HYMNS will be useful not only for studies of HA but also for future investigations of other neuromodulators.
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITY OF NEWCASTLE UPON TYNE · Newcastle Upon TyneКоординаторОбединеното кралство
- MASSACHUSETTS INSTITUTE OF TECHNOLOGY · CambridgeСъединени щати
- UNIVERSITAET BERN · BernШвейцария
Връзки
Данни: CORDIS, © Европейски съюз