BioNanoProbes · Bio-Inspired Glycan-NanoProbes as Antimicrobial Pro-Drugs
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2019-05-01 → 2021-04-30
- Финансиране от ЕС
- 212 934 €
- Участници
- 1
- Схема
- MSCA-IF
Линиите свързват координатора с партньорите.
Накратко на български
Биовдъхновени нанозонди от захари се разработват за бързо разпознаване на специфични бактерии и доставяне на лекарства. Това помага за по-точното предписване на антибиотици и борбата с бактериалната резистентност.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Bio-Inspired Glycan-NanoProbes as Antimicrobial Pro-Drugs
Antimicrobial resistance (AMR) is a recognized global challenge. Tools for bacterial detection can combat AMR by facilitating evidence-based antibiotic prescribing, thus avoiding empirical use that can contribute to the spread of resistance. Unfortunately, traditional culture-based identification methods take at least a day, while emerging alternatives are limited by high cost and requirement for skilled operators. The proposal “Bio-inspired glycan-nanoprobes as antimicrobial prodrugs” (BioNanoProbes) has evaluated glycan-CDots as tools for rapid detection of specific bacteria, establishing their viability, together with the quantum photonic sensor (QPS) detection developed by our industrial partner Fluoretiq, as the basis for a rapid diagnostic method. There is no doubt that success in this endeavour can have a major impact in organic synthesis, glycobiology, molecular medicine and drug discovery. Owing to the urgent for novel antimicrobials that target specific bacterial populations, objectives of this Marie Sklodowska Curie Action (MSCA) have been to develop of new chemical tools that can be used to label bacteria and/or delivery of antimicrobial drugs. The novelty of this approach lies not only in the synthetic schemes, but also in the approach and their potential biological applications of the proposed bio-inspired glyco-nanoprobes as antimicrobial pro-drugs. In summary, the proposed work represents an ambitious and wide ranging multi- and interdisciplinary research programme aimed at developing the next generation of antimicrobials to overcome antibiotic resistance.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Methods for specific recognition and targeting of bacteria are of key importance in developing approaches to counter the growth of antimicrobial resistance (AMR). Cell surface carbohydrates play key roles in cell recognition mechanisms and bacterial adhesion. These key interactions typically exhibit high specificity and weak affinities toward their carbohydrate ligand. This low affinity is compensated in nature by the architecture of the protein, the host presenting the carbohydrate ligands in a multivalent manner or as clusters on the cell or mucosal surface. Glyco-nanomaterials offer the possibility of attaching several different molecules to the same nanoparticle while controlling the relative densities of these ligands. Recently, the Galan group demonstrated that a simple disaccharide, such as lactose can act as a “Trojan horse” on bi-functionalized fluorescent nanopartiples (CdSe QDs) to help intracellular delivery of other non-internalizable glycan moieties and largely avoid the endosomal/lysosomal degradative pathway. Following this, the group has developed a new class of water-soluble, non-toxic fluorescent carbon-based nanomaterials which are easily accessible from cheap carbohydrate starting materials and more excitingly, preliminary data have shown that these new carbon nanodots are able to label both Gram-negative and Gram-positive bacteria. Based on these exciting results, the aim of this project is to develop a new class of glycan-based nanoprobes for labelling and delivery of antibiotics into bacteria. The glycan-based nano pro-drugs will be evaluated in bacterial binding and killing assays and screened for selective labelling and drug release using confocal microscopy and TEM. This is a multidisciplinary project involving synthetic organic and materials chemistry, glycobiology and microbiology.
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITY OF BRISTOL · BRISTOLКоординаторОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз