H2020Индивидуална стипендия2021–2023

INTENDeD · INTegration of EmotioNs During Decision-Making

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-03-01 → 2023-02-28
Финансиране от ЕС: 203 149 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Невронните връзки в мозъка на мишки се проучват чрез наблюдаване как те реагират на вкусови награди. Разбирането на тези процеси помага да се разбере как емоциите влияят върху вземането на решения и при кои психически разстройства този механизъм е нарушен.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

INTegration of EmotioNs During Decision-Making

Emotions are often contrasted with reason. However, the integration of emotional information into the decision-making processes can advantageously bias adaptive behavior selection. Miss-regulation of emotional information integration in cortical processing is a hallmark of psychiatric disorders with affect dysregulation. Our knowledge of the etiology and pathophysiology of these disorders is strongly limited by our understanding of the non-pathological neuronal circuits underlying emotional processing and makes targeted intervention methods scarce. The project addressed how valence and value representation is encoded in the BLA using in vivo two-photon calcium imaging during a newly established unpredicted gustatory reward delivery paradigm in mice. This allowed us to characterize gustatory value representations in detail. Leading to the description of how neuronal value representations are maintained and modified across different stimulus contrasts, physiological needs, and affective states. We find dynamically updated value signals, which could be used to determine the reinforcing properties of a stimulus, while at the same time allowing for sensory-specific associations, thereby providing a flexible basis for adaptive learning and decision-making. The results obtained here will inform our continued characterization of whether the BLA transmits differential valence and value information to specific PFC subregions and how BLA information is integrated in the local PFC circuit. The long-term basic research goal is to achieve a circuit- and cellular-level mechanistic understanding of the influence of BLA activity on PFC processing and decision-making. Characterizing the BLA – PFC network in the healthy brain will serve as a reference for the characterization and optogenetic modulation of abnormalities in disease model mice, ultimately providing a roadmap for a translational path, like optogenetically-inspired deep-brain stimulation in human patients.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Emotions are often contrasted with reason. However, integration of emotional information into the decision-making processes can advantageously bias adaptive behavior selection. Miss-regulation of emotional information integration in cortical processing is a hallmark of psychiatric disorders with affect dysregulation. Our knowledge of the etiology and pathophysiology of these disorders is strongly limited by our understanding of the non-pathological neuronal circuits underlying emotional processing and makes targeted intervention methods scarce. I here propose to investigate information transfer between two hub regions involved in valence assignment to environmental stimuli and integration of this information in decision making. Gaining insight into the long-range connectivity between the basolateral complex of the amygdala (BLA) and the medial prefrontal cortex (mPFC) and the integration of BLA information in the local mPFC circuit in mice will significantly advance our understanding of emotional processing during decision making. I hypothesize that the BLA can influence the mPFC in a valence-specific manner. To address how valence representation encoded in the BLA biases action selection in a decision-making task, I am going to train mice in a cost-benefit task and modulate valence-specific BLA projections to the mPFC. Furthermore, using in vivo two-photon calcium imaging and state-of-the art long range connectivity mapping methods, I will characterize if the BLA transmits differential valence information to specific mPFC subregions. Finally, I will investigate how valence-specific BLA information is integrated in the local mPFC circuit, using optogenetics based functional connectivity mapping methods in the acute brain slice preparation. This research will allow for the first time to achieve a circuit and cellular level mechanistic understanding of the influence of positive and negative valence coding in the BLA on mPFC processing and ultimately decision-making.

Оригинален текст от CORDIS (на английски).

Участници

FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION · BASELКоординаторШвейцария