BioNanoLip · Bioactive lipids at the ocular surface: from Langmuir surface balance to ophthalmic nanoemulsions
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2020-01-06 → 2022-01-05
- Финансиране от ЕС
- 159 815 €
- Участници
- 1
- Схема
- MSCA-IF-EF-ST
Линиите свързват координатора с партньорите.
Накратко на български
Липидният слой на слъзния филм и неговото взаимодействие с наноемулсии се анализират чрез микроскопия и специални измервания. Това помага за разбирането на механизмите при сухота в очите и глаукома, което може да подобри терапиите за тези заболявания.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Bioactive lipids at the ocular surface: from Langmuir surface balance to ophthalmic nanoemulsions
The tear film lipid layer (TFLL) is a microscopically thin film of oils that is key to preventing the tear film from evaporating. Dry eye disease develops when this lipid layer malfunctions and affects up to 30% of the human population across the globe. Mixing ophthalmic nanoemulsions with the tear film lipid layer, which has an exceptionally slow turnover rate, could lead to improved treatments for dry eye disease as well as for glaucoma, a major vision-threatening disease. The BioNanoLip project aims to increase our understanding of lipid layer functionality and dry eye disease mechanisms. It also explores molecules and formulations that can enhance lipid layer functionality and lead to new therapies. In the course of the action meibomian and tear layers were studied with diverse range of mutually complimentary techniques and approaches: Langmuir surface balance, Brewster angle microscopy, fluorescence microscopy and spectroscopy, in situ and in vivo model systems. Thus it was possible to characterize (i) the dynamic interfacial properties and structure of the meibomian and tear film at natural and model air/tear surface, (ii) to elucidate the contribution of the individual lipid, tear and pharmaceutical molecules to the performance of the layers in vitro and in vivo and (iii) to probe the correlation between the structure and the dynamic interfacial properties of the films.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Since 2012 the interest to the studies of the tear film lipid layer (TFLL) stabilizing the air/tear surface has dramatically raised. Firstly TFLL related abnormalities may be the main reason for dry eye syndrome (DES), the most prevalent ophthalmic public health disease affecting the quality of life of 10-30% of the human population worldwide and resulting in > €3.5 billion annual cost for EU. Secondly due to TFLL exceptionally slow turnover rate of 0.93 (±0.36)%/min, ophthalmic nanoemulsions mixing favorably with it can gain long residence at the ocular surface allowing for new routes of treatment not only of DES but also of glaucoma, the major vision threatening disease today. Therefore it is important to study the impact of key lipid classes to the micro- and nano-scale structure and to the dynamic surface properties of TFLL films at the air/water interface in health and disease and in vitro and vivo. This is what we will do by employing state of the art Langmuir surface balance, dilatational rheology, fluorescence and Brewster angle microscopy techniques as well as pharmacokinetic methodologies. The action will deliver both, (i) fundamental knowledge on TFLL functionality and DES mechanisms and (ii) molecules and formulations that can enhance TFLL functionality and lead to new therapies. The action will allow to European science and industry to aim for leadership in a field of increasing social importance.
Оригинален текст от CORDIS (на английски).
Участници
- INSTITUTO SUPERIOR TECNICO · LisboaКоординаторПортугалия
Връзки
Данни: CORDIS, © Европейски съюз