H2020Индивидуална стипендия2019–2021

MIDLIFT · Mid-infrared laser system for high-throughput bioprinting by laser-induced forward-transfer

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2019-10-01 → 2021-09-30
Финансиране от ЕС: 212 934 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Нова лазерна система в средната инфрачервена област се разработва за прецизно биопринтиране на биологични материали. Тя позволява локално предаване на енергия в тъканите, което помага за по-точното им обработване и рязане при различни медицински приложения.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Mid-infrared laser system for high-throughput bioprinting by laser-induced forward-transfer

The main goal of this project was the development of a novel nanosecond laser system, which operates in the wavelength range near the peak absorption wavelength of liquid water (2930nm). Laser radiation at these wavelengths has a penetration depth of few µm in water, enabling highly localised energy deposition and strong laser-material interactions in biological tissues. The development of high-power nanosecond laser sources at these wavelengths has the potential to enable the high precision processing, cutting, and printing of biological materials in a variety of medical applications and lead to significant advances European healthcare. The MIDLIFT laser system was developed to provide nanosecond pulses with sufficient pulse energies and peak powers to enable the precision processing of biological materials—specifically for applications in bioprinting by mid-infrared laser-induced forward-transfer (LIFT). To overcome the limitations of previously demonstrated laser sources in this wavelength range, we proposed a master-oscillator power-amplifier (MOPA) approach: to combine a compact, gain-modulated GaSb-diode laser with a single-mode Erbium-doped fluoride fibre amplifier. In the final part of the project, it was planned to demonstrate the application of the new laser system for mid-infrared LIFT bioprinting. At the end of the project a new nanosecond MOPA laser system operating at a wavelength of 2790nm was demonstrated. We achieved output pulse energies of 52.7µJ, pulse durations of 5.2ns, and peak powers of more than 8kW at a repetition rate of 10kHz, from an Erbium-doped fluoride fibre amplifier with a nearly diffraction-limited output beam profile (M2 < 1.3).

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The goal of this Fellowship is the development of a novel mid-infrared laser system for high-throughput bioprinting by laser-induced forward-transfer (LIFT). The Fellow will develop a high repetition-rate, high-power, nanosecond laser system emitting at exactly 2.9 µm (the peak absorption wavelength of liquid water). The strong absorption of the mid-infrared laser output in biomaterials will be utilised for the demonstration of a new bioprinting technique: mid-infrared LIFT of biomaterials. It will overcome the main drawback of conventional biomaterial LIFT, which is the reliance on additional absorber layers and contamination of printed materials with metallic debris. Mid-infrared LIFT will enable high-throughput (10k droplets/s), high-resolution (picolitre droplets) 3D-printing of biomaterials without metallic contamination and will be a highly promising platform for tissue fabrication.The mid-infrared laser system will be realised with a gain-switched quantum-cascade diode laser and multiple Er-doped fluoride-fibre amplifier stages. The laser system will be designed to provide 25 ns pulse durations, 10-30 µJ pulse energies, 100 kHz repetition rate, and laser emission at 2.9 µm wavelength. This laser system will be integrated into an existing LIFT setup and used for the first demonstration of mid-infrared LIFT bioprinting. The Fellow is an early-stage postdoc, who has resumed his research career after a 5-year period working in industry. He is an expert in fibre laser development and will be trained in quantum-cascade-lasers, gain-switched diode lasers, LIFT, and bioprinting. The complementary training will include communication and dissemination of research results, commercialisation of research output, and acquisition of research and innovation project funding. The Fellowship will enable the Fellow to establish a unique scientific profile, build a research network, and reach professional maturity.

Оригинален текст от CORDIS (на английски).

Участници

ASTON UNIVERSITY · BirminghamКоординаторОбединеното кралство