H2020Индивидуална стипендия2020–2022

EUREKA · Design of multifunctional phosphorous dendritic systems for drug delivery

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2020-02-04 → 2022-02-03
Финансиране от ЕС: 196 708 €
Участници: 1
Схема: MSCA-IF-EF-ST

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Накратко на български

Фосфорните дендримери са разклонени молекули, които се използват за транспортиране на лекарства до клетките. Тези биоматериали помагат за доставянето на вещества, които трудно се усвояват от организма.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Design of multifunctional phosphorous dendritic systems for drug delivery

Dendritic molecules - dendrimers and dendrons - are hyperbranched macromolecules, composed of monomers associated radially from a central core. Due to their repetitive structure, dendritic molecules can be considered as polymers, but in contrast to polymers, they are never synthesized by polymerization reactions, but step-by-step in an iterative fashion, creating layers. Dendrimers are widely used in different fields of science and technology, such as catalysis, materials chemistry and regenerative and cell biology. In particular, the last direction is highly emerging, since new innovative therapeutics are now required for modern medicine, with dendrimer exhibiting a number of prospective properties. When modified with hydrophobic moieties, dendrimers and dendrons can form supramolecular associates in water media. This is very useful for the delivery of poorly bioavailable bioactive molecules into cells. The goal of the project is to develop novel dendrimer-based biomaterials for drug delivery and translational medicine. The objectives of the project are: 1. Overall training – Trainings to make the Fellow a highly skilled independent researcher with a strong knowledge base 2. Multifunctional dendrimers and dendrons – Development of strategies to obtain dendritic systems bearing different functional groups 3. Self-organization of dendritic molecules – Study of the formation of supramolecular assemblies by the multifunctional dendrons/dendrimers. 4. Drug binding – Study of the drug complexation with cationic dendrimers and with the dendron-based supramolecular assemblies. 5. Biological effect – Screening of the biological properties of formulations obtained 6. Industrial application – Harmonizing the developments made and products obtained with industrial requirements for easier transfer into practice. These objectives have been fully accomplished. The results obtained bring new, highly efficient therapeutic constructions for antitumor therapy. Furthermore, the project has set a background for future developments in the field, including production of novel therapeutics.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The aim of the project is to provide the interdisciplinary training to young talented researcher Dr. Evgeny Apartsin, specialist in biomaterials science and nucleic acid therapy, to become highly qualified world class researcher. The Applicant proposes an interdisciplinary approach for the design of multifunctional phosphorous dendritic systems for the delivery of therapeutic nucleic acids in vitro and in vivo. During the project implementation, novel stimuli-sensitive supramolecular constructions based on phosphorous dendrimers and dendrons will be created to be used as carriers for chemodrugs and nucleic acids. The synthetic part of work will be done in the Host organization, which is world leading institution in the dendrimer science and applications. The physics-chemical and biological parts will be done in collaboration with the Partner organization together with recognized specialists in biophysics, molecular and cell biology. At the last stage of the project, the synthesis of best candidate therapeutic constructions will be transferred to the industry. The Applicant will receive numerous scientific trainings from the experts in macromolecules and medicinal chemistry, molecular biology and industrial technology as well as additional trainings on project management and funding, public dissemination of results, presenting and teaching. The trainings and the implementation of this project (knowledge, skills, papers, patents, etc.) will help the Applicant to be efficiently integrated into the European and international science at highest level.

Оригинален текст от CORDIS (на английски).

Участници

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS · ParisКоординаторФранция