H2020Индивидуална стипендия2019–2021

LongPlaNet · Long-Range Plasticity of Neuronal Networks in the Adult Brain

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2019-10-01 → 2021-11-11
Финансиране от ЕС: 184 708 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Невронните връзки в мозъка на възрастни се проучват чрез промяна на сетивния опит, например чрез премахване на висриците при мишки. Разбирането на тези процеси помага при търсенето на нови терапии за невродегенеративни заболявания, психични разстройства и травми.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Long-Range Plasticity of Neuronal Networks in the Adult Brain

LongPlaNet (Long-Range Plasticity of Neuronal Networks in the adult Brain) aimed to study the plastic potential of the adult brain. Modifying the sensory experience (ex. permanently removing the tactile whiskers in mice) we challenge the brain to adapt. When this happens in the younghood, neuronal connections are reshaped to optimize the use of the affected brain regions. However, when sensory experience is modified during the adulthood, no major structural readjustments seem to take place, and although cross-modal adaptation to sensory loss or motor learning are present in the adult age, the mechanisms underlying these processes are poorly understood. LongPlaNet challenged this dogma, studying in detail the nature of structural plasticity in the adult brain. Understanding the potential of the adult brain to experience plastic readjustments will set the basis do further understand axonal stability and degradation in the adult brain, a key process in the search for new therapeutic targets for neurodegenerative diseases, traumatic injuries, or psychiatric diseases in our aged societies. The overall objectives of the action are summarized as: - Analysis of changes in long-range connectivity after sensory deprivation. - Study of the transcriptional changes after sensory deprivation. - Longitudinal assessment of circuit function.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Brain plasticity is well studied in the developing and early life, but how experiences can reshape the brain during adulthood is still poorly understood. Non-invasive medical imaging techniques point to the existence of broad functional readjustments in adult brain networks. However, a good understanding of the biological underpinnings of this phenomenon is lacking. Deciphering the nature of adult brain structural readjustments may lead to a breakthrough in our understanding of the mechanisms underlying many psychiatric and neurodegenerative disorders, and potentially lead to therapeutic alternatives for these highly prevalent diseases in a globally aging population. LongPlaNet seeks to study the dynamics of long-range projections in the adult brain. To reach this goal I will use an array of cutting-edge techniques allowing me to study WHOLE BRAIN CONNECTIVITY at a CELLULAR RESOLUTION in the context of ADULT BEHAVING MICE. I will start from a preliminary list I generated of candidate brain regions undergoing plastic readjustments following long-term sensory deprivation in the mouse. I will quantify using 3D whole brain imaging by light-sheet microscopy the structural changes of connectivity between these regions. I will then use RNA-seq and bioinformatic tools to find markers of neuronal plasticity. Finally, I will track by in vivo calcium imaging with two-photon microscopy the evolution of the receptor fields of neurons affected by plastic remodeling. The present action will pioneer the intersection of molecular, structural and functional characterization of a well known but poorly understood phenomenon of adult reorganization of neuronal networks.

Оригинален текст от CORDIS (на английски).

Участници

INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE · ParisКоординаторФранция