H2020Индивидуална стипендия2019–2021

SCHEME · Sewage chemical information mining – development of a novel concept for the assessment of human exposure to pollutants through wastewater analysis

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2019-10-01 → 2021-09-30
Финансиране от ЕС: 160 932 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Биомаркери от козметика и битови препарати се търсят в градските отпадни води, за да се проследи излагането на хората към химикали. Този метод помага за по-лесното оценяване на влиянието на замърсителите върху здравето на населението.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Sewage chemical information mining – development of a novel concept for the assessment of human exposure to pollutants through wastewater analysis

Humans are nowadays exposed to an increasing number of environmental contaminants. Our exposure to these potentially harmful substances can be assessed by human biomonitoring (HBM) studies, which involve the analysis of specific biomarkers (excreted parent compounds and/or metabolites) in urine and other biological matrices from individuals. Due to several limitations of this approach, which involves complex cohort studies, a novel concept, based on the analysis of human biomarkers in municipal wastewater (sewage), often referred to as wastewater-based epidemiology (WBE) or sewage chemical information mining (SCIM), was proposed. So far, WBE has been successfully applied to assess human exposure to pesticides, mycotoxins, phthalates, alternative plasticizers, phosphorus flame retardants/plasticizers (PFRs) and bisphenol A. However, most of these studies were exclusively focused on one specific class of compounds, while studies which would include larger number of biomarkers from different groups are still very scarce. The aim of the SCHEME project was to develop a multiresidue analytical method for the determination of biomarkers of human exposure to chemicals from personal care and household products. To accomplish this goal, three specific objectives were established: (i) To select an appropriate set of biomarkers of human exposure to selected chemicals; (ii) To develop a reliable multi-class analytical methodology for their monitoring in wastewater and to demonstrate its analytical feasibility; (iii) To demonstrate the applicability of the WBE/SCIM approach for the assessment of human exposure to selected chemical substances.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Human populations worldwide are exposed to a large number of chemical pollutants from contaminated food, personal care products and the surrounding environment. Exposure to these compounds is generally assessed by human biomonitoring - the analysis of biomarkers (excreted parent compounds or metabolic products) in biological matrices from individuals, mostly urine. Due to the several limitations of this approach, a novel concept - sewage chemical information mining (SCIM), has been proposed. This approach is based on the analysis of specific human biomarkers in urban wastewater, but its potential in studying human exposure to pollutants has been scarcely investigated.The SCHEME project aims to contribute to the practical development and broadening of the SCIM field by developing a comprehensive analytical methodology for the determination of biomarkers of exposure to a wide range of organic pollutants, including different classes of personal care products and industrial chemicals. The biomarkers will be selected using the pharmacokinetics data and Human Metabolome Database and analysed by ultrahigh performance liquid chromatography - tandem mass spectrometry. The developed methodology will be applied in four European cities as case studies. However, the results of this exploratory study could lead to implementation of this novel, relatively inexpensive and near real-time approach for the assessment of human exposure to pollutants. By monitoring temporal and spatial trends, communities with the highest exposure could be promptly identified. Therefore, the results of the SCHEME project will be highly valuable for obtaining relevant epidemiological information and will contribute to preventing human health problems related to pollutants exposure. The fellow’s expertise, gathered in top international research institutions, and the outstanding infrastructure and capabilities available at ICRA, makes an ideal conjunction for the successful completion of the project.

Оригинален текст от CORDIS (на английски).

Участници

FUNDACIO INSTITUT CATALA DE RECERCA DE L'AIGUA · GironaКоординаторИспания