H2020Индивидуална стипендия2019–2021

ProgNanoRobot · Programmable NanoRobotics for Controlled Manipulation of Molecular Cargoes

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2019-04-01 → 2021-03-31
Финансиране от ЕС: 224 934 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Програмируеми нанороботи с разгъваеми „ръце“ се разработват за пренасяне на молекулярни товари, управлявани чрез светлина. Тези системи помагат за разбирането на начина, по който молекули могат да бъдат премествани точно и насочено между различни станции.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Programmable NanoRobotics for Controlled Manipulation of Molecular Cargoes

ProgNanoRobot project proposed the development of artificial robotic systems that could be programmed to transport molecular cargoes in a programmable fashion. The project intended to take the design of first generation of molecular robots to the next level of sophistication by studying key methodologies needed to manipulate molecular fragments through small-molecule programmable robotics. Four objectives were initially established: 1.Explore and develop a toolbox of robotic machine components 2.Use a chemical fuel to operate the molecular robotic systems 3.Develop a programmable molecular machine for transport of molecular cargoes over long distances 4.Produce a molecular robot capable of selectively pick-up and reposition cargoes using an extendable robotic arm Several types of light-switchable robotic arms were studied to understand their rules of operation, allowing to control the robotic systems with good efficiencies using light as stimulus. Progress towards the synthesis of a ‘bucket-brigade’ molecular device, in which a substrate can be passed directionally from one robotic arm to the next, was described. Several molecular models that constitute functional parts of the full molecular machine were produced separately and their operation conditions were tested. A molecular machine capable of orthogonally switching both the reach and the orientation of its robotic arm was developed. The position of the arm with respect to different stations in a molecular platform can be controlled using light. Functional ‘half-machine’ models were synthesized and progress towards selective transport of a molecular cargo between different stations was carried out. Time allocation required to carry out the synthetic work of this project was higher than initially expected. The complex behavior of these systems forced the iterative redesign and synthesis of model compounds, gradually introducing alterations and testing its efficiency in order to improve operation. The COVID-19 pandemic also affected the development of the project due to the total shutdown of activities in the University of Manchester from March to July 2020 and the restriction of activities from August 2020 to the end of the action. This unforeseen circumstance occurred in a critical stage of the project, heavily affecting general development and progress.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Molecular machines are among the most complex of all functional molecules and lie at the heart of nearly every biological process. The controlled manipulation of molecular-level structures through programmable small-molecule robotics is a fabulous challenge that could lead us towards the dawn of an era of useful molecular nanotechnology.“ProgNanoRobot” project aims to design, construct and investigate the operation of artificial molecular nanorobots capable of transporting a molecule cargo in a programmable fashion. We will develop key methodologies needed to manipulate molecular fragments using a molecular robotic arm operating through the formation and cleavage of dynamic covalent bonds, building on a rotary switch in which the rotor and stator can be positioned with respect to each other. We will explore different component types to find the best programmable small-molecule robotic systems and develop a toolbox of robotic machine components. We will use them as the basis for molecular machines that can transport molecular cargoes of biological relevance over long distances and to select between different cargoes and move them between multiple sites on molecular platforms in either direction. Moreover, we will employ a chemical fuel that induces pH oscillations in the reaction medium to allow the autonomous operation of these systems, a key development to reach the full potential of molecular machines, which will enable them to work as effective molecular assembly lines.We envisage that the domain of this new generation of molecular robotics will be useful for the development of molecular-sized machines that can manipulate substrates to control sequence-specific oligomer construction and molecular manufacturing.

Оригинален текст от CORDIS (на английски).

Участници

THE UNIVERSITY OF MANCHESTER · ManchesterКоординаторОбединеното кралство