NUTREPHEALTH · Effect of polyinsatured fatty acids omega-3 (PUFAS n-3) supplementation during early embryo development on embryo viability in (mammals) sheep.
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2020-02-01 → 2022-05-20
- Финансиране от ЕС
- 183 473 €
- Участници
- 1
- Схема
- MSCA-IF
Линиите свързват координатора с партньорите.
Накратко на български
Добавянето на омега-3 мастни киселини, например чрез ленено масло, влияе върху жизнеспособността на ембрионите при овцеподобните бозайници. Това помага за намаляване на ранните загуби на бременности и ограничава зависимостта от химически хормони при животните.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Effect of polyinsatured fatty acids omega-3 (PUFAS n-3) supplementation during early embryo development on embryo viability in (mammals) sheep.
Reproductive failure has been the subject of a wide spectrum of studies related meanly to livestock production as well as to human health fields. Some of these studies have been addressed to resolve problems associated to infertility, more specifically, during first days of pregnancy/early stage of pregnancy. However, despite of the efforts to maintain outstanding reproductive performance, the reproductive failures are still considerable. This reproductive failure is related to a failure in maternal-embryo communication during early stage of pregnancy. In fact, 25 to 55% and 40 to 55% of embryonic losses -in sheep herds and cattle, respectively - occur during the early stage of pregnancy. In this sense, nutritional factor is one of the most important issues involved in the reproductive efficiency. The strategic use of nutraceutical products (nutrient with therapeutic effect) is considered as an alternative tool for resolving the reproductive failures during early stage of pregnancy. In this sense, the use of polyunsaturated fatty acids like omega-3 (PUFASn-3) has a positive effect on human and animal health (involving numerous biological process such as vision, growth, brain development, and reproduction). Nevertheless, their effect on fertility -specifically during early stage of pregnancy- have been controversial and non-conclusive, justifying the necessity to perform further studies. Linseed oil is considered an important botanical source of PUFASn-3 used in animal feeding. Thus, its effect on fertility indexes in livestock species would has positive impact on livestock. In addition, its implementation guarantee/enhance the animal welfare, due to that it contributes to diminish the dependence of chemical products (e.g. hormones) commonly used intensive reproductive management. In consequence, it would reduce the residues in body tissues and contribute to offer healthy products (e.g. milk and meat) for human consumption impacting positively on public health and reducing health care cost. Considering the above mentioned, the aim of the present project was evaluating the mechanism that exert the dietary supplementation of by-pass linseed oil during embryo-maternal recognition of pregnancy using ovine species a mammal model. In this study, linseed oil effect was evaluated at embryonic and maternal levels (individually) as well as on embryo-maternal cross-talk/relationships.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
It is well known, that an adequate fertility rates has important outcomes in different species of mammals (including human). However, despite the efforts to maintain outstanding reproductive performance, the reproductive failures are still considerable. This reproductive failure is related to a failure in maternal-embryo communication. In this sense, nutritional factor is one of the most important issues involved in the reproductive efficiency. Some studies have indicated that the use of polyunsatures fatty acids (PUFAS) like omega-3 have a positve effects on human and animal health. Nowadays, the effects of diets rich in PUFAS omega-3 (PUFASn-3) on reproductive physiology have been studied assensing the follicular function, ovulation rate and oocyte quality. In addition, there is scarce information about of the mechanism and/or effectiveness of PUFASn-3 during peri-implantational period in mammals. However the outcomes obtained have been controversiel and non-conclusive, justifying the necesity to perform futher studies. Thus, the combined use of morphologic studies, hormonal assays, genomics and proteomics procedures and embryo recover/transfer technologies could be suitable methodologies to evaluate the effects of PUFASn-3 during peri-implantational period. Also, these tools could evaluate the maternal/endometrial signal (e.g: receptors expression) and gene embryonic expressions during this period. In consequence, these studies could assess the effectiveness of PUFASn-3 on maternal and/or embryo’s level. The results obtained, will contribute to enhance the productivity in animal production system. Furthermore, the use of ovine species has been a classical experimental model in human medical studies. Thus, the awarness obtained in this proposal would contribute to increase the fertility rate in women with reproductive failure during this periodreinforcing the inter/multidisciplinary dimension of this proposal (impacting in life science and agricultural fields).
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITA DEGLI STUDI DI SASSARI · SassariКоординаторИталия
Връзки
Данни: CORDIS, © Европейски съюз