H2020Индивидуална стипендия2021–2023

SchiSTOP · Beyond mass drug administration: understanding Schistosomiasis dynamics to STOP transmission

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-05-03 → 2023-05-02
Финансиране от ЕС: 175 572 €
Участници: 2
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Шистозомията и причините за бързото завръщане на инфекцията при хората след масово лечение с лекарства се анализират чрез математически модели. Това помага за подобряване на стратегиите за контрол на болестта и намаляване на бедността в засегнатите региони.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Beyond mass drug administration: understanding Schistosomiasis dynamics to STOP transmission

Neglected tropical diseases (NTDs) are a diverse group of infections which are especially prevalent in low-income populations in tropical and subtropical areas in Africa, Asia and the Americas. Schistosomiasis is the deadliest NTD killing an estimated 280,000 people each year in the African region alone. The World Health Organization (WHO) 2030 target for schistosomiasis is its elimination as a public health problem (EPHP) in all endemic countries and the interruption of transmission in 32% of the endemic countries. Mass drug administration (MDA) with the anthelmintic drug praziquantel is the primary measure for the control of schistosomiasis. However, in areas of moderate and high prevalence the goal seems unlikely to be met as even with intensive biannual MDA, prevalence of infection has been seen to rebound rapidly after each round. The reasons are still poorly understood. The SchiSTOP project aims to advance our current understanding of schistosomiasis transmission dynamics investigating the mechanisms that cause the rapid rebound of prevalence after MDA and proposing optimal implementation of current and novel strategies to achieve schistosomiasis control and move towards elimination. In addition, this project builds a reference methodological framework to comprehensively study other MDA-targeted infectious diseases. The proposed project addresses one of the priorities of the EU, through global poverty reduction (SDG goal 1) by promoting ways of improving future health (SDG goal 3). Mathematical models and statistical methods have proven to be essential to gain insights into the complex processes underlying the transmission dynamics of infectious diseases. The overarching goal of the SchiSTOP project is to advance our understanding of schistosomiasis transmission dynamics by developing a stochastic agent-based model (ABM) to simulate schistosomiasis transmission integrating cutting-edge mathematical models and statistical methods with recent advances in parasite genetics, epidemiology, diagnostics and immunology.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Neglected tropical diseases (NTDs) are a diverse group of infections which are especially prevalent in low-income populations in tropical and subtropical areas in Africa, Asia and the Americas. Schistosomiasis is the deadliest NTD killing an estimated 280,000 people each year in the African region alone. The World Health Organization (WHO) 2020 target for schistosomiasis is to reduce the prevalence of heavy-intensity infections to ≤5% among school-aged children through Mass Drug Administration (MDA). However, in areas of moderate and high prevalence the goal seems unlikely to be met as even with intensive biannual MDA, prevalence of infections are still seen to rebound rapidly after each round. The reasons are still poorly understood. Mathematical models and statistical methods have proven to be essential to gain insights into the complex processes underlying the transmission dynamics of infectious diseases. In this research project, I will develop a stochastic individual-based model (IBM) to simulate schistosomiasis transmission integrating cutting-edge mathematical models and statistical methods with recent advances in parasite genetics, epidemiology, diagnostics and immunology. This project aims to advance our current understanding of schistosomiasis transmission dynamics investigating the mechanisms that cause the rapid rebound of prevalence after MDA and proposing optimal implementation of current and novel strategies to achieve schistosomiasis control and move towards elimination. In addition, this project will build a reference methodological framework to comprehensively study other MDA targeted infectious diseases. The proposed project addresses one of the priorities of the EU, through global poverty reduction (SDG goal 1) by promoting ways of improving future health (SDG goal 3).This project will be carried out at Erasmus MC with Prof. Sake J. de Vlas and at University of Glasgow (secondment) with Dr. Poppy Lamberton.

Оригинален текст от CORDIS (на английски).

Участници

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM · NijmegenКоординаторНидерландия
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM · RotterdamНидерландия