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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Докторантска мрежа2019–2023

DohART-NET · Periconceptional Programming of Health Training Network

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2019-07-01 → 2023-11-30
Финансиране от ЕС
3 398 006 €
Участници
20
Схема
MSCA-ITN

Линиите свързват координатора с партньорите.

Накратко на български

Влиянието на условията преди и по време на зачеването, включително при ин витро оплодняване, върху развитието на сърдечно-съдови и метаболитни заболявания при децата. Разбирането на тези механизми помага за по-ефективна превенция и персонализирано лечение на тези заболявания.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Periconceptional Programming of Health Training Network

Altered conditions during the periconceptional (PC) period of gamete maturation and early embryonic development have long lasting effects on the health of the progeny, including the childhood, adolescent and adult-life onset of cardiovascular, metabolic and neurological diseases (DOHaD concept). Increasing evidence from epidemiological and animal model studies shows that children worldwide exhibit conditions and disease risks associated with the exposures of their parents, including chemical stressors before and during pregnancy, reproductive failure, adverse pregnancy outcome, diabetes, obesity and nutritional compromise. Babies born following human Assisted Reproductive Technology (ART, “test-tube”) interventions render this population (over 8 million world-wide) one of the largest well-defined clinical cohorts to be studied for a better understanding of the future risk of disease for current and succeeding generations in Europe. The DohART-NET project focuses on the integration of pre-clinical (animal and stem cell-models) and clinical studies and applies data linkage, bioinformatics and network science for the identification and validation of mechanisms of diseases common in early development. We will exploit our new understanding to promote efficient disease prevention and potential personalised therapeutic interventions in both the general and ART populations to overcome adverse disease pathways.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Altered conditions during the periconceptional (PC) period of gamete maturation and early embryonic development have long lasting effects on the health of the progeny, including the childhood, adolescent and adult-life onset of cardiovascular, metabolic and neurological diseases (‘Developmental Origins of Health and Disease (DOHaD) concept). Increasing evidence from epidemiological and animal model studies shows that children worldwide exhibit conditions and disease risks associated with the exposures of their parents, including chemical stressors before and during pregnancy, reproductive failure, adverse pregnancy outcome, diabetes, obesity and nutritional compromise. Babies born following human ART (“testtube”)interventions render this population (over 5 million world-wide) one of the largest well-defined clinical cohorts to be studied for a better understanding of the future risk of disease for current and succeeding generations in Europe. The DohART-NET project focus on the integration of pre-clinical (animal and stem cell-models) and clinical studies and apply data linkage, bioinformatics and network science for the identification and validation of mechanisms of diseases common in early development. We will exploit our new understanding to promote efficient disease prevention and potential personalised therapeutic interventions in both the general and ART populations to overcome adverse disease pathways. DohART-NET is optimized for training ESRs due to the facts that: i) the topic is progressive and much needed to improve public health over several generations, and it is integrating basic pre-clinical, translational clinical and in silico modeling approaches, iii) the partnership has a highly multi- and interdisciplinary scientific and training expertise and excellence, iv) there is an existing synergy by collaborations and links that the partners wish to strengthen both in science and lasting training programs in a highly inter-sectorial setting.

Оригинален текст от CORDIS (на английски).

Участници

Връзки

Данни: CORDIS, © Европейски съюз