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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Докторантска мрежа2020–2024

BIOMOLMACS · Molecular Machines Functioning in Cells

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2020-01-01 → 2024-06-30
Финансиране от ЕС
4 107 786 €
Участници
12
Схема
MSCA-ITN

Линиите свързват координатора с партньорите.

Накратко на български

Молекулярните машини се интегрират в изкуствени клетки и липидни наночастици, за да се създадат системи за пренос на лекарства и ваксини. Това помага за подобряване на медицинската диагностика и по-точното доставяне на активни вещества до органите.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Molecular Machines Functioning in Cells

The BIOMOLMACS project aimed to create a multidisciplinary training network focused on the rapidly advancing field of molecular machines. Significant efforts have been made in recent decades to develop these machines, and the project sought to integrate them into practical devices, with a strong potential for applications in nanomedicine. By combining molecular machines with precisely designed synthetic macromolecules, the project created a robust molecular toolbox for innovative applications, particularly in medical diagnostics and drug delivery systems. A key objective was to train the next generation of bionanotechnology researchers, equipping them with the skills to design targeted polymeric biomedically active compounds. The project focused on four main objectives, which were collectively addressed by the network. These included developing molecular machines, designing artificial cells, understanding biophysical interactions, and advancing drug/gene delivery systems. Significant progress was made, including the incorporation of molecular motors into lipid nanoparticles and artificial cells, mechanobiology studies, and the successful design of liposomes containing molecular motors. The project also achieved promising results in understanding biophysics, with synthetic organelles performing designated tasks within cell-like structures. Additionally, innovative polypeptide-based systems were developed for targeting mitochondria, and lipid-based nanoparticles encapsulating saRNA were assessed for their potential in vaccine formulations. Overall, the BIOMOLMACS project made substantial strides in advancing molecular machines and their integration into practical applications. It resulted in the development of new technologies with potential real-world applications, such as stimuli-responsive systems and artificial cells. The project’s impact is demonstrated by its contribution to 32 scientific publications, four patent filings, and ongoing manuscripts. BIOMOLMACS has successfully bridged fundamental research with practical applications, paving the way for future breakthroughs in nanomedicine and synthetic biology, and training highly skilled researchers for these emerging fields.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The main motivation of BIOMOLMACS training network is to establish a multidisciplinary training network on the emerging topic of molecular machines and to train the next generation of highly-skilled researchers in this exciting field. In the last decade, great efforts have been spent on the development of synthetic strategies for the creation of molecular machines, and these efforts have been acknowledged by the Nobel committee in 2016. In parallel, synthetic and polymer chemistry fields have made significant advances in the last decade, to the point that we are able to design and control the sequence of individual repeat units along synthetic macromolecules. Sequence controlled polymers open up greater possibilities in the precise formation of nanoparticles such as polymersomes, and even support the new generation of artificial cells. The synthetic combination of molecular machines and precisely designed synthetic macromolecules will open new avenues for innovative nanobiomedical applications. Early Stage Researchers of BIOMOLMACS will be trained on the design, chemical synthesis, and biophysical characterization of such complex macromolecular architectures as well as their incorporation in artificial and living cells. Finally, biophysical understanding of the molecular interactions in living/synthetic systems will be able to bridge the gap between fundamental and applied research in this exciting field.

Оригинален текст от CORDIS (на английски).

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Връзки

Данни: CORDIS, © Европейски съюз