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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Докторантска мрежа2019–2024

SAND · Secretion, Autophagy and their role in Neurodegeneration

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2019-11-01 → 2024-10-31
Финансиране от ЕС
4 076 578 €
Участници
17
Схема
MSCA-ITN

Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.

Накратко на български

Механизмите за почистване и транспорт на протеини в клетките се изследват чрез примери като болестите на Алцхаймер и Паркинсон. Разбирането им помага за откриване на нови маркери за диагностика и цели за създаване на лекарства срещу невродегенеративните заболявания.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Secretion, Autophagy and their role in Neurodegeneration

Neurodegenerative disorders (NDs), such as Huntington's disease (HD), Parkinson's disease (PD), and Alzheimer's disease (AD), pose significant health challenges in our aging society and are among the leading causes of death. These disorders often involve the accumulation of toxic protein aggregates, like amyloid plaques and Lewy bodies, and subsequent neuronal death in specific parts of the central nervous system. These aggregates can arise from familial or sporadic genetic mutations in the proteins themselves or from disruptions in cellular proteostasis, which is the balance of protein production, sorting, and turnover. The secretory and autophagic pathways are crucial regulators of proteostasis, and their dysfunction can lead to NDs. The SAND project aimed to deepen our understanding of these pathways and their roles in NDs. The specific objectives included: 1) uncovering the fundamental mechanisms of the autophagy and secretory pathways and their interactions; 2) clarifying how these pathways contribute to NDs; and 3) identifying new drug targets and diagnostic markers for tackling NDs. Through their work on various SAND projects, a new generation of early-stage researchers (ESRs) has been trained in essential scientific and transferable skills for future careers in academia or industry.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Neurodegenerative disorders are among the leading causes of mortality and will become more relevant in our continuously aging societies. Most neurodegenerative disorders exhibit alterations in proteostasis, i.e. an imbalance between protein production, sorting and degradation. The secretory and the autophagic pathways are two major regulators of cellular proteostasis and their crosstalk is likely to be relevant for neurodegeneration. Thus, there is a need to train a new generation of early stage researchers that will exploit and translate the fundamental biology principles of autophagy, secretion and their crosstalk in human diseases. Our ETN will explore the links between Secretion, Autophagy and their role in NeuroDegeneration (SAND) and will consolidate the position of Europe as a leader in this field by: (i) providing a framework for training and supervision of students to provide them with a repertoire of transferrable and scientific skills that will equip them for careers in academia and industry. (ii) bringing together leading experts in the fields of autophagy, secretion and neurodegeneration from academia and industry into a consortium that involves 22 participants from 12 countries (12 academic beneficiaries from 13 institutions, 3 industry beneficiaries, 4 non-academic partners and 3 academic partner institutions) (iii) using a unifying strategy such as a common stock of cell lines for screening and a common electronic custom-made database tailored to the needs of our consortium (iv) combining complementary expertise such as systems biology, chemical biology, model organisms (zebrafish, drosophila and mouse models), cellular models (neuronal cell lines, primary neurons and patient-derived iPSC neurons) and techniques (e.g. EM, intravital imaging, proteomics, microfluidics) (v) exploiting the translational potential because the network contains three clinically active neurologists, non-academic partners interested in development of drugs and diagnost

Оригинален текст от CORDIS (на английски).

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Връзки

Данни: CORDIS, © Европейски съюз