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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Обмен на изследователи2020–2025

VIDEC · Visualizing Death Inducing Protein Complexes

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2020-01-01 → 2025-06-30
Финансиране от ЕС
1 237 400 €
Участници
13
Схема
MSCA-RISE

Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.

Накратко на български

Взаимодействията между специфични протеини, като Apaf-1 и caspase-9, се анализират, за да се открият молекули, които блокират свързването им. Това помага при разработването на нови методи за лечение на рак, възпаления и невродегенеративни заболявания като болестта на Паркинсон.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Visualizing Death Inducing Protein Complexes

The project contributes to the international and inter sectoral integration of European research through a programme that supports researcher mobility between European countries, Third Countries and between industry and academia. This mobility supports knowledge exchange and researcher training through projects focused on human diseases and drug-development, with the aim of finding new treatments for disease. This research is also more widely relevant to areas that include increased food security by improving aquaculture and better protection from chemical hazards by improved methods of toxicity assessment. The disease research focusses on problems particularly relevant to an aging population (like Europe’s) and include neurodegenerative diseases (e.g., Parkinson’s disease), cancer (e.g., Diffuse Large B Cell Lymphoma), and inflammation. This is being accomplished by studying how proteins bind to each other to cause human disease and then searching form drug-like chemicals to block the binding and cure the disease. The specific protein-protein interactions being investigated are the binding of Apaf-1 to itself and to caspase-9, the binding of CARD11 to BCL10, the binding of RIPK1 to RIPK1, the binding of NLRP3 to itself and to caspase-1, the binding of ASC to caspase-1 and the binding of caspase-2 to RAIDD. The overall objective is to identify at least one drug-like molecule that blocks a protein-protein interaction and that reduces or prevents disease-associated changes.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Every day billions of cells die in our bodies as part of normal healthy processes. These cell deaths are called “regulated cell deaths” as they occur through the activation of genetically encoded molecular machinery. However, too little or too much cell death is the cause of various diseases and of illness caused by exposure to chemicals. Understanding these cell death processes and how they are controlled may lead to new treatments for disease as well as explaining why some chemicals are hazardous. Regulated cell deaths as exemplified by apoptosis, necroptosis, and pyroptosis are induced by the formation of protein complexes. Here, we will develop new molecular tools to visualize the formation of the protein complexes in live cells and tissues and then use these tools to study cell death in normal and disease processes. Our consortium includes cell death experts, bioluminescence experts, zebrafish experts, as well as structural, developmental, molecular and cell biologists in industry and academia. The proposed research network will provide intersectoral mobility between laboratories expert in complementary skills. This will drive the development of the new tool and enhance the researchers’ career prospects. The research is of importance to many citizens of the EC; it will contribute to increasing food security by improving aquaculture, improving the health of aging populations through the study of degenerative diseases, improving toxicity assessment to better protect citizens from chemical hazards and improving the drug-development by better identification of adverse effects. Moreover, the assays emerging from the research will be commercialized by the industrial partners in the network, so supporting economic development within the EU.

Оригинален текст от CORDIS (на английски).

Участници

Връзки

Данни: CORDIS, © Европейски съюз