H2020Индивидуална стипендия2021–2023

COMEDM · Common mechanisms for decision-making and working memory in health and old age

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-01-18 → 2023-01-17
Финансиране от ЕС: 184 591 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Работната памет и вземането на решения – например когато помним информация, за да изберем правилното действие – може да зависят от едни и същи мозъчни механизми. Разбирането на тази връзка помага да се обяснят когнитивните затруднения при възрастните хора и при някои психични разстройства.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Common mechanisms for decision-making and working memory in health and old age

We are regularly required to keep recently encountered information about the world in mind, and to use that information to make appropriate decisions. These essential cognitive functions, known as working memory (WM) and decision-making (DM), respectively, have typically been studied separately. Yet, recent developments in theoretical and systems neuroscience suggest that both WM and DM could emerge from a shared set of neural mechanisms. This is an exciting proposal, as it points to a new, integrative view on the neural basis of higher cognition; a view through which the multifaceted changes in WM and DM behaviour present in psychological and neuropsychiatric disorders affecting millions worldwide may be localized to single, potentially treatable loci of neural dysfunction. With this project, hosted by Trinity College Dublin, we aimed to interrogate the extent to which WM and DM are reliant on shared mechanisms in the human brain. We employed a suite of cutting-edge approaches in cognitive neuroscience to provide strong convergent support for this idea. We also took initial steps toward applying insights from these investigations to assess a possible shared neural basis for the WM and DM deficits that are known to exist in a large portion of the global population: healthy older adults. As such, our research both offers a new, unified perspective on fundamental building blocks of cognition, and points to ways in which this can be exploited to understand conditions of brain change and disorder.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

We are constantly required to keep recently encountered information about the world in mind, and to use that information to make appropriate decisions. These essential cognitive functions, known as working memory (WM) and decision-making (DM), are conventionally studied in isolation by psychologists and neuroscientists. Yet, recent theoretical developments suggest that both DM and WM could emerge from the same fundamental neural mechanisms. With this Marie Skłodowska-Curie Fellowship, hosted by Trinity College Dublin and IDIBAPS Barcelona, I will empirically test this exciting proposal for the first time. In my career thus far, I have characterised new neural signatures of DM and established a non-invasive proxy for powerful neural systems linked to both DM and WM. Now, I will supplement these breakthroughs with a number of cutting-edge approaches in cognitive neuroscience specialised in by my host supervisors Prof. Robert Whelan and Dr. Albert Compte. This suite of tools will allow me to expose commonalities between DM and WM at an unprecedented level of detail, and interrogate a possible common neural basis for DM and WM deficits that exist in a large part of the global population – healthy elderly individuals. During my Fellowship, I will publish my findings in leading journals and work to communicate my research activities to the largest possible audience. I will participate in professional development programs to develop essential competencies in personnel management and grant writing, and will capitalise on my secondment in Barcelona to grow my global research network. Additionally, I will receive advanced training in sophisticated methodological and analytical approaches, which will continue my progression toward becoming a leading cognitive neuroscientist capable of competing for high-level funding opportunities. Thus, this Fellowship will prepare me well for a future career as the principle investigator of a multidisciplinary European research laboratory.

Оригинален текст от CORDIS (на английски).

Участници

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN · DublinКоординаторИрландия