H2020Индивидуална стипендия2020–2022

HarmHoney · HeAlth Regulation by the gut Microbiota in the Honey bee

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2020-05-01 → 2022-10-27
Финансиране от ЕС: 203 149 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Чревните бактерии на пчелите разграждат вещества от полена, като например флавоноидите, които помагат за пречистването на организма от пестициди. Разбирането на този процес помага да се разбере как да се поддържа здравето на пчелите и да се запази екосистемата.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

HeAlth Regulation by the gut Microbiota in the Honey bee

Given the current decline in honey bee populations, understanding their physiology, and how to maintain their health, is critical to preserve our ecosystem. As for humans and most animals, the gut microbiota was shown to play an important role in honey bee health. It degrades the pollen ingested by bees and release non-nutritive compounds in the gut lumen. Among them, flavonoids increase the expression and activity of P450 enzymes in the bee body, thereby promoting the detoxification of some pesticides and buffering their detrimental effects on bees’ survival. Recently, gut bacteria were shown to metabolize flavonoids and to favor the absorption of the resulting products through the host gut epithelium. The importance of this metabolism for the bioactivity of flavonoids was unknown. The broad hypothesis of the granted project was that the decomposition of pollen compounds (e.g. flavonoids) by the gut microbiota would have a beneficial impact on honey bee health. In line with this hypothesis, the objectives of the project were to (i) highlight the importance of the gut microbiota for bee health, (ii) identify the flavonoids whose conversion by the gut microbiota may affect bee health, (iii) assess the impact of neonicotinoid pesticides on the gut microbiota composition, and (iv) understand the extent to which flavonoid-conversion by the gut microbiota may protect bees from health alterations by pesticides.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

When feeding on plants, animals ingest non-nutritive compounds produced by the plant which are converted by the metabolic activity of bacteria present in their gut and act on their physiology. Some of these phytochemicals, the flavonoids, provide health benefits in many species, but little is known about the modulation of their bioactivity by the gut microbiota.Here, we want to understand the importance of the gut microbiota in modulating flavonoids' effects on honey bee health under physiological conditions and after exposure to neonicotinoid pesticides. Honey bees are vital pollinators to our ecosystem and the current decline in their population is alarming. The neonicotinoids have been identified as one of the responsible factors. Using 16S rRNA sequencing and metabolomics approaches, we aim at identifying the combinations of flavonoids and gut symbionts promoting bee health and resistance to neonicotinoids. Bee health will be assessed both under laboratory and field conditions by measuring the survival rates, the activity of the detoxification pathway and the maturation speed because stressed bees have been shown to start foraging younger than healthy bees.The outcome of this project will be of interest for a large range of scientific communities from microbiologists to ecologists, both in fundamental and applied sciences. Promoting health by acting on diet and gut bacteria is a hot topic, as is the decline in bee populations. Dissemination of the results to the general public will be facilitated by the existing enthusiasm for these questions.The applicant will share her knowledge of the honey bee physiology and behavior with the host laboratory and will gain from its expertise in gut microbiota function. She will acquire the skills necessary to apply for junior researcher positions at the end of the fellowship and to focus her career on the importance of the gut microbiota and diet for honey bee health, both at the physiological and behavioural level.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITE DE LAUSANNE · LAUSANNEКоординаторШвейцария