H2020Индивидуална стипендия2020–2022

GelPrint · Printable polypeptide hydrogels with antimicrobial properties

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2020-04-01 → 2022-03-31
Финансиране от ЕС: 184 591 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Полипептидните хидрогели се тестват като 3D принтируеми материали, които могат да се използват за превръзки при рани. Те помагат за ограничаване на бактериалния растеж, което е важно заради нарастващата устойчивост на микробите към антибиотиците.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Printable polypeptide hydrogels with antimicrobial properties

Biomaterials with antimicrobial properties which can be used for wound healing and tissue engineering applications offer high application potential due to the global increase of antimicrobial resistance. While polypeptides own this potential, their integration into a materials platform has not been realised to date. The overall objective of this project is to develop 3D printable antimicrobial or bacteriostatic polypeptide hydrogel materials, which can be employed in tissue regeneration applications to prevent bacterial growth. In particular, the goals include synthesis of sets of cross-linked polypeptide hydrogels based on lysine (Lys) and investigation of their hydrogel properties and 3D printability. The project is broadly interdisciplinary, as disciplines of polymer chemistry, biomaterials science and engineering, microbiology and in vitro assessment techniques will be combined. The project objectives were met by the synthesis of a set of novel hydrogel forming star polypeptides by ring-opening polymerisation containing different amnio acid compositions. Through evaluation of their rheological properties and cell compatibility, a lead materials was identified which combined excellent antimicrobial properties against E. Coli, was extrudable and printable while displaying good cell compatibility. This proof of concept demonstration confirms their feasibility in tissue regeneration, specifically in wound dressing applications. The results demonstrate for the first time that through compositional and structural optimisation of synthetic polypeptides their biomaterial properties can be tuned to address biomedical challenge.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Biomaterials with antimicrobial properties which can be used for wound healing and tissue engineering applications offer high application potential due to the global increase of antimicrobial resistance. While polypeptides own this potential, their integration into a materials platform has not been realised to date. The overall objective of this project is to develop 3D printable antimicrobial or bacteriostatic polypeptide hydrogel materials, which can be employed in tissue regeneration applications to prevent bacterial growth. In particular, the goals include synthesis of sets of cross-linked polypeptide hydrogels based on lysine (Lys) and investigation of their hydrogel properties and 3D printability. Moreover, evaluation, validation and quantification of the antimicrobial properties of the hydrogels as well as the proof of concept demonstration for their feasibility in tissue regeneration will be addressed. The synthesis of these particular copolypeptides hydrogels is highly novel and their exploitation as a printable tissue regenerating platform is timely, of high fundamental as well as clinical impact and considered a new approach. The proposed project is broadly interdisciplinary, as disciplines of polymer chemistry, biomaterials science and engineering, microbiology and in vitro assessment techniques will be combined. The high-level science combined with complementary training will significantly advance the career opportunities of the applicant. Moreover, the excellent match of the applicant`s expertise with the project and the host organisation will ensure a strong transfer of knowledge between all participants. The potential of the proposed project is further highlighted by the possible commercial exploitation of the scientific findings and developments. Finally, it will enable new collaboration opportunities between research groups from different scientific fields.

Оригинален текст от CORDIS (на английски).

Участници

ROYAL COLLEGE OF SURGEONS IN IRELAND · DUBLIN 2КоординаторИрландия