MAMBO · Magnetic swArms for liver chemoeMBOlization
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2020-09-01 → 2023-08-31
- Финансиране от ЕС
- 252 525 €
- Участници
- 2
- Схема
- MSCA-IF
Линиите свързват координатора с партньорите.
Накратко на български
Магнитни микророботи, управлявани чрез ултразвук, се разработват за прецизно доставяне на лекарства и запушване на кръвоносни съдове в черния дроб. Това помага за подобряване на химиотерапията и намаляване на страничните ефекти при лечението на рак.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Magnetic swArms for liver chemoeMBOlization
MAMBO aims at enforcing the employment of robotic technologies in the field of medicine, towards the development of robotically-enabled high efficiency therapeutic strategies and towards the strengthening of the EU leadership in this field. Cancer is one of the three main causes of mortality worldwide and current therapeutic approaches produce severe side-effects or incomplete eradication. Controverting the standard paradigms by penetrating into the hard-to-reach areas of the human body and selectively performing therapy in a controllable fashion appears as the holy grail in cancer treatment. Untethered microrobots wirelessly activated through magnetic fields could help in this direction. However, before any microrobot-based therapeutic paradigm can reach the clinical practice, several challenges still need to be faced. MAMBO (Magnetic swArms for liver chemoeMBOlization) proposes the use of swarms of drug-loaded, US-responsive, magnetic microrobots for targeted liver chemoembolization. The proposal stems from the idea to improve cancer chemotherapy and existing chemoembolization procedures by using magnetic forces to collect chemotherapeutics in the target region (through swarm control methods) and to controllably and stably embolize tumor blood vessels. Drug loaded soft magnetic microrobots featured by responsiveness to ultrasound are being developed to this aim. The responsivity to US enables microrobot swelling and controlled vessel occlusion and at the same time allows their ultrasound-based imaging to guarantee their tracking in vivo. Magnetic swarm control techniques are employed to enable microrobots locomotion in biologically-relevant fluids. US-mediated phase transition mechanisms is employed to trigger embolization and drug release, whereas advanced ultrasound imaging techniques will be employed during the overall procedure to enable sub-resolution tracking of the swarm and performances evaluation (Figure 1). MAMBO aims to train the proponent for developing novel technologies to enable the employment of swarms of magnetic, echogenic drug-loaded microrobots for optimized chemoembolization. To accomplish this goal, three sub-objectives were identified: - Development of the multifunctional magnetic microrobots. They should (i) present swarm behavior, (ii) swell on demand to enable vessel embolization, (iii) encapsulate and release drugs and (iv) enable ultrasound-based imaging. - Magnetic swarm control strategy compatible with navigation in the blood to enable target blood vessels reaching and in situ accumulation. - Ultrasound based imaging of the microrobots swarm to monitor its action.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Magnetically actuated untethered microrobots have been proposed in the state of the art since more than a decade towards the dream of accessing remote hard to reach areas of the human body. Nevertheless, some challenges still have to be faced before any microrobot-based therapeutic paradigm can reach the clinical practice. MAMBO (Magnetic swArms for liver chemoeMBOlization) aims at facing some of these challenges by targeting a specific clinical application, namely liver chemoembolization.The proposal stems from the idea to improve cancer chemotherapy and existing chemoembolization procedures by using magnetic forces to collect chemotherapeutics in the target region (through swarm control methods) and to controllably and stably embolize tumor blood vessels. Drug loaded soft magnetic microrobots featured by responsiveness to ultrasound will be developed to this aim. The responsivity to US will enable microrobot swelling and controlled vessel occlusion and at the same time their ultrasound-based imaging to guarantee their tracking in vivo. Magnetic swarm control techniques will be employed to enable microrobots locomotion in biologically-relevant fluids. MAMBO will last 36 months and is articulated in a 24 months outgoing phase carried out at the Chinese University of Hong Kong (CUHK – partner organization) and in a 12 months return phase in Scuola Superiore Sant’Anna (SSSA – beneficiary organization). In the framework of the project I will try to deepen my skills in magnetic swarm control by benefiting from the major expertise of Prof. Li Zhang’s group. At the same time, I will share with them my background in medical robotics and drug delivery systems towards the development and testing of a novel therapeutic paradigm for cancer treatment. During the return phase at SSSA I will focus on the US imaging of the developed microrobots thanks to the Interaction with Prof. Menciassi’s group and to their expertise in US-based technologies.
Оригинален текст от CORDIS (на английски).
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Данни: CORDIS, © Европейски съюз