H2020Индивидуална стипендия2020–2022

PRECISMEDLYM · Aggressive T cell Lymphomas, integrated clinical and genomic analysis for a precision medicine.

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2020-09-28 → 2022-09-27
Финансиране от ЕС: 160 932 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Агресивните Т-клетъчни лимфоми се анализират чрез търсене на молекулярни биомаркери и изучаване на туморната среда. Това помага за по-точна диагноза и избор на специфично лечение с по-малко странични ефекти за пациентите.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Aggressive T cell Lymphomas, integrated clinical and genomic analysis for a precision medicine.

T-cell lymphoma is a heterogeneous group of aggressive non-Hodgkin lymphomas associated with a poor clinical outcome. T and B-cell lymphomas classification is complex and involved a combination of clinical, histological and immunohistochemical markers, however frequently has a low reproductivity. Importantly, this classification is critical for patient diagnosis and treatment. Although, recent advances in molecular biology techniques have contributed additional tools for providing more accurate diagnosis and new therapeutic targets, nowadays the need for reliable diagnostic and prognostic markers remains partially unmet. T and B-cell non Hodgkin lymphomas constitute malignant neoplasms with an adverse outcome and low probability of survival. Furthermore, these patients are exposed to high toxicity treatments which are not specific for the different types of diseases. Current integrative clinical and molecular studies are improving the identification of specific subtypes, allowing the recognition of targeted therapy and prognostic markers with a minimum toxicity and maximum clinical benefit for the patients. The objectives of the PRECYSMEDLYM project were the identification of new molecular biomarkers of prognostic utility in the context of precision medicine; perform an in-depth analysis of cellular subpopulation in microenvironment tumor; design new monoclonal antibodies using the biomarkers previously identified. Conclusions: The accomplishment of the PRECYSMEDLYM project has allowed the routine application of molecular techniques in clinical patient samples with different types of lymphoma. Moreover, we have provided a better understanding of the pathogenesis of the corresponding lymphoma subtypes, as well as proposed diagnostic, predictive and prognostic molecular signatures.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Lymphoid leukemias and lymphomas represent frequent areas of the tumour pathology. Recent Integrative clinical and molecular studies allows to identify concrete disorders where a precise recognition leads to a specific treatment with a minimum toxicity and maximum clinical benefit. Even though there have been many progress during last years, there still persist numerous conditions with low survival probability and high side effects of the received treatments. The introduction of the precision medicine in lymphoid neoplasms is new and challenging due to the scarce knowledge about disease pathogenesis, targeted therapies and predictor markers, immunotherapy role and poor experimental models.T-cell lymphoma tumors present a dismal survival probability dismal (25% for Peripheral T-cell lymphoma) in patients, and the molecular mechanism underlying their high rate of lack response to treatments and relapse is poorly understood. Furthermore, patients with lymphoproliferative disorders often have complex (multiclonal) or mixed lymphoproliferative disorders.This project aim the consolidation of the precision medicine in the diagnosis and therapy of these disorders, thus facilitating the treatment of each patient according its disease, with specific therapy according to the integral characterization of its disease, thus reducing toxicity and improving the therapy efficacy.The project focuses on complex lymphoproliferative diseases characterized by clinical aggressiveness with low therapeutic response, tumor heterogeneity and patterns of dependency / interaction with the microenvironment. The success of the project requires in first instance to improve in the knowledge of the molecular basis of the disease and subsequently in the identification of precise tumour types and patient stratification, thus facilitating the identification of markers for targeted therapy, using gene expression and mutational signatures.

Оригинален текст от CORDIS (на английски).

Участници

INSTITUTO INVESTIGACION SANITARIA FUNDACION JIMENEZ DIAZ · MadridКоординаторИспания