H2020Индивидуална стипендия2020–2022

POSTURENET · Postural networks: linking cognitive and motor control across the lifespan

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2020-09-01 → 2022-08-31
Финансиране от ЕС: 187 572 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Невронните мрежи, които координират мускулите за поддържане на равновесие, се променят с възрастта. Разбирането на тези процеси помага за откриване на маркери, които предсказват риска от падане при възрастните хора.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Postural networks: linking cognitive and motor control across the lifespan

This aim of the project was to investigate the role of neural synchronization in postural control and to investigate how the neural coordination involved in postural control changes across the lifespan. To this end, a new network approach was developed to investigate human postural control and how neural coordination breaks down with ageing. The ageing population in Europe will have a major impact on economy and well-being, resulting in an increase in motor impairments and movement-related disorders. It is estimated that every year within the EU 3.8 million older people attend emergency departments with a fall-related injury and 35,000 die as a consequence of falls. Although many factors influencing fall risk have been identified, e.g., muscle loss and impaired sensation, little remains known about changes in neural coordination of posture across the lifespan. In this project, muscle network analysis is proposed as a novel approach to assess postural control across the lifespan. The aims of the project are to: • Investigate the mechanisms underlying postural networks and determine the role of cortical sensorimotor cortices • Investigate the functional role of postural networks and assess how executive control modulates the coordination between muscles • Investigate how postural networks changes across the lifespan to gain new insights into the motor impairments observed with normal ageing The overall objective of the project is to evaluate the age-related changes in postural control that can be revealed by this new network approach. The outcomes of this fellowship may provide new markers of physiological changes that predict fall risk and identify potential targets of interventions to reduce falls.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Almost every movement we make requires the coordination of multiple muscles. How the central nervous system coordinates these patterns of muscle activity remains largely unknown. Here I propose muscle networks as an innovative and principled approach towards neural interactions underlying coordinated movements and posture to address this outstanding problem. Recent findings show robust patterns of neural coupling across multiple muscles. Application of network theory has brought about a paradigm change in brain research and has been crucial for understanding how neurons and neuronal structures connect and communicate. Here I will extend the approach used to study brain networks to the neuromuscular system and investigate the neural interactions within the brain and spinal cord involved in postural control using network analysis of brain and muscle activity (EEG & EMG). By relating network structure to postural kinematics obtained using 3D motion-capture technology, I will investigate the functional role of postural networks in healthy participants performing postural tasks and to map changes in postural control across the lifespan. Cognitive control and sensorimotor functions will be assessed using standardized test and correlated with network metrics to explain variability in postural control and disentangle their role in organizing of postural networks. By combining advanced computational analyses with state-of-the-art recording techniques, the project will enable reconstructing functional interactions in the distributed motor system from non-invasive recordings. Postural networks hence offer a promising new perspective on a long-standing open question in movement neuroscience. The expertise of my supervisors and the excellent facilities at Maastricht University provide an ideal environment in which to conduct this project and establish my own research group at a leading research institute in Europe.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITEIT MAASTRICHT · MaastrichtКоординаторНидерландия