H2020Индивидуална стипендия2020–2022

NeuroVascOme · Gut microbiota-Neurovascular Interactions in Early Life

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2020-07-01 → 2022-06-30
Финансиране от ЕС: 196 591 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Чревните микроорганизми влияят на защитните бариери на развиващия се мозък чрез вещества, които попадат в кръвта. Разбирането на този процес е важно, тъй като фактори като цезарово сечение или антибиотици нарушават микробиотата и са свързани с невроразвиващи се разстройства.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Gut microbiota-Neurovascular Interactions in Early Life

The brain relies on a constant composition of its environment for proper development and function, maintained by the ‘brain-barriers’. These barriers also constitute an interface of communication between peripheral cues and the brain. One such source of peripheral signals is the gut-microbiota - an ecosystem of trillions of microorganisms that populate our guts. Though alterations in microbiota are associated with several neurodevelopmental disorders such as autism spectrum disorder (ASD), schizophrenia and attention deficit hyperactivity disorder (ADHD), the exact mechanisms of communication are largely unknown. The NeuroVascOme project asked whether this microbiota regulates the barriers in the developing brain through compounds that are produced by our gut microbes and reach the circulating blood, and consequently affect brain microenvironment and function. Understanding this is particularly important given the multiple factors that are known to disrupt our microbiota, such as antibiotics, stress and birth by Caesarean section (C-section). C-section bypasses the birth canal, where the initial microbiota seeding happens, through vertical transmission of vaginal and faecal maternal microbiota to the new born. Moreover, this intervention is highly relevant in our society; according to recent research from World Health Organisation (WHO), C-section use continues to rise globally, now accounting for more than 1 in 5 (21%) of all childbirths. While C-section can be an essential and lifesaving surgery, it can put women and babies at unnecessary risk of short- and long-term health problems if performed when there is not medical need. One of the known risks of C-section, as mentioned above, is the disruption of the vertical transmission of maternal vaginal and faecal microbes to the new born. Moreover, a recent study showed that mice born by C-section display behavioural and cognitive deficits, that can be rescued by gut-microbiota based interventions, such as administration of pre- or probiotics. Overall, we know little about the impact of gut microbiota disruption on our brains, especially in early life, when the brain is particularly vulnerable. Understanding how C-section can impact the developing brain through the disruption of the early-life microbiome, is essential for developing future microbiota-based strategies to enhance the microbiota composition in this vulnerable population.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The prenatal and early postnatal life are particularly vulnerable phases for brain development, during which essential neurodevelopmental processes occur. One such vital process is the development of the neurovascular unit resulting in the formation of blood brain barrier (BBB), which is the gateway regulating access of the external milieu to the brain. Concomitant with the postnatal BBB development, the maturation of our resident gut microbiota also occurs during this sensitive period of early life. Altered gut microbial composition has been shown to affect BBB function and is increasingly being linked to adverse health outcomes including neurodevelopmental disorders, such as autism or attention deficit hyperactivity disorder. However, an exact mechanistic understanding of how this early life alteration in microbiota composition leads to brain dysfunction is not known. The NeuroVascOme project aims to investigate the link between early life microbiota perturbations and neurovascular development, which in turn is crucial for brain homeostasis. And more precisely, how are the different disruptors of microbiome in early life impacting the neurovascular/BBB integrity, thereby predisposing the organism to health deficits in later life. This is especially relevant for our modern-day society wherein early life microbiome disruptions caused by increased stress, antibiotic administration and caesarean delivery methods are widely prevalent. In accordance with the aims of the MSCA fellowships, NeuroVascOme project will greatly aid my career development by providing first rate training in academic and industry settings that will enhance my research skillset, foster my managerial abilities and strengthen my professional network. Additionally, public, industry, and scientific audiences will be informed about the outcomes of the project through a dissemination strategy that will aim to promote the role of early life environment in shaping mental health.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK · CorkКоординаторИрландия