H2020Индивидуална стипендия2020–2022

SIGNAL · Sensing Neuro-immune Activation in the Lung microenvironment

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2020-04-01 → 2022-03-31
Финансиране от ЕС: 224 934 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Взаимодействието между нервната и имунната система се проучва чрез модели на мишки, за да се разбере как невроните влияят върху алергиите и астмата в белите дробове. Това е важно, за да се разбере как стресът засилва или потиска имунните реакции при заболявания.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Sensing Neuro-immune Activation in the Lung microenvironment

SIGNAL, a Horizon 2020 MSCA project, seeks to understand how our neurons can affect the immune response in the context of mucosal immunity (e.g. in the lung, female reproductive tract…). We aim to develop experimental mouse models to investigate these interactions (neuro-immune crosstalk) and better comprehend whether a subgroup of our immune cells is specialized to translate neuronal-derived cues during immune responses. We focus on how the neuro-immune crosstalk participates in allergy and asthma. While the scientific and medical communities have studied allergies and asthma for a long time, and have developed superior treatments for these pathologies, there is still much about the causes and prevalence of allergies that we do not understand. Stress can trigger asthma attacks, worsen allergies, and even promote autoimmune disorders. We still do not understand why or how this happens, but recent investigations are starting to reveal that the nervous system plays a pivotal role in controlling immune responses to pathogens and allergens. In some instances, our nervous system boosts the immune response and promotes inflammation, while in other cases it suppresses the immune system. We do not comprehend the mechanisms behind this discrepancy. We require precise knowledge of how the interaction between the immune and nervous systems affects our immunity in health and disease. Here is where SIGNAL tries to provide insight into this question: we want to contribute to understanding the neuro-immune crosstalk so eventually this knowledge translates into better management of immune-related pathologies. The overall aims of the project are to develop technical tools and scientific pre-clinical laboratory models to study how the activation or inhibition of specific types of neurons influence the immune response during allergic reactions. SIGNAL intends to define how controlling distinct groups of neurons affects allergic inflammation in the lung. In addition, SIGNAL aims to investigate whether the input from neurons into the immune system affects all immune cells to a similar extent or whether some immune cells are specialized in sensing the cues derived from neurons. If we can identify immune cells that are dedicated to coordinate the neuro-immune crosstalk, we plan to study their biology.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The immune system is indispensable for our defense against infections, and plays an essential role in homeostasis, where compartmentalization and specialization are key aspects of every immune cell. Microenvironmental cues (e.g. stromal cell-derived signals) are integrated by the cell networks forming the immune system to maintain immune tolerance or promote immunity against an antigen. Recent findings suggest that neurons also contribute to curb the immune response; they produce neuropeptides that act directly on immune cells such as dendritic cells and neutrophils. However, our understanding of neuroimmune interactions is superficial: we ignore whether specialized cell subsets are responsible for integrating neural cues, we lack precision when studying these connections, and it is unknown whether neuroimmune exchanges are relevant in different tissues and immune reactions, as with the case of lung immune responses related to allergy and chronic obstructive disorders. Asthma has been shown to present a neurological component not yet entirely linked to the immune system. To gain insight into neuroimmune modulation, SIGNAL aims to elucidate the presence and function of neuro-sentinel innate lymphoid cells (nsILC) in the lung: ILC dedicated to detect and translate neuro-derived signals. ILC are tissue resident immune cells which are pivotal coordinators of immune homeostasis, bridging the innate and the adaptive immune system. Using a multidisciplinary approach by combining the selectiveness of optogenetics and chemogenetics with the unbiased power of detection of single cell genomics, and the comprehensiveness of mouse in vivo models, I have setup myself to discover and define nsILC in the context of type-2 responses in the lung. My work will develop our understanding of neuroimmune interactions, and their influence in allergy and asthma, potentially discovering pathways which will provide the context for new approaches in treating this type of disorders.

Оригинален текст от CORDIS (на английски).

Участници

UNITED KINGDOM RESEARCH AND INNOVATION · SWINDONКоординаторОбединеното кралство