H2020Индивидуална стипендия2020–2023

MAGIC · Development of antibacterial MetAllic Glass mICrofibers

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2020-10-01 → 2023-09-19
Финансиране от ЕС: 171 473 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Метални стъкла от цирконий, мед и сребро се изследват за създаване на микровлакна, които да спрат бактериите по имплантите. Това помага за подобряване на безопасността на медицинските изделия и намаляване на инфекциите при пациентите.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Development of antibacterial MetAllic Glass mICrofibers

The project "MAGIC" addresses the critical issue of infections caused by bacterial biofilm formation on metallic implants in the medical field. This is a significant problem as it often leads to the failure and retrieval of these implants. The importance of this issue for society lies in its direct impact on healthcare, particularly in the context of increasing antibiotic resistance and the high incidence of healthcare-associated infections. The project aims to develop a deeper understanding of the antibacterial mechanisms in Zr-Cu-Ag metallic glasses (MGs), a material recently known for its intrinsic antibacterial properties. The overall objectives of the project are threefold: • To understand how the chemical composition of Zr-Cu-Ag MGs influences their antibacterial activity. • To explore the effect of surface energy of these MGs on their antibacterial mechanisms. • To innovate in the field of biomaterials by fabricating microfibers from these antibacterial MGs, enhancing their applicability in medical devices. By achieving these objectives, the project seeks to advance the integration of antibacterial metallic glasses in the medical industry, potentially improving the longevity and safety of metallic implants and contributing significantly to public health.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The proposed training-through-research aims to develop novel antibacterial materials for medical devices based on Zr-Cu-Ag metallic glasses in the form of microfibers. The major cause of metal implants retrieval is infection due to bacterial biofilm formation on their surface. Many studies have been conducted on the development of antibacterial coating on metallic implants, but evidence has shown numerous drawbacks associated with coatings including their lack of durability. “MAGIC” project proposes the development of Zr-Cu-Ag metallic glasses with generic and intrinsic antibacterial properties which makes them capable of battling antibiotic resistance bacterial infection with no further required coating. Meaningful development of this novel class of intrinsic antibacterial metals requires a fundamental understanding of their antibacterial mechanism which to date is not well-understood. Therefore, “MAGIC” project fundamental ambition is to discover the underlying antibacterial mechanism of innovative Zr-Cu-Ag metallic glasses though a novel interdisciplinary approach, combing materials engineering knowledge of metallic glasses with advanced biological analysis of bacteria. On the engineering side, the main antibacterial contributors “chemical composition” and “surface energy” of Zr-Cu-Ag metallic glass will be modified and controlled; On the biological analysis side, bacterial genetic and metabolic response to these changes will be studied by coupling basic metabolic assays with next-generation sequencing and omics techniques. Furthermore, to facilitate the integration of antibacterial metallic glasses in the medical industry, “MAGIC” has an applied ambition to fabricate the best found Zr-Cu-Ag metallic glass (in terms of chemical composition and surface energy) in the form of microfibers for the very first time. Microfibers have higher surface areas and are easier to be formed into different shapes, offering added value to their applicability in industry.

Оригинален текст от CORDIS (на английски).

Участници

POLITECNICO DI TORINO · TorinoКоординаторИталия