MUSIC · Metabolic regulation of reciprocal signalling between skeletal muscle cell types
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2020-09-01 → 2022-08-31
- Финансиране от ЕС
- 184 708 €
- Участници
- 1
- Схема
- MSCA-IF
Линиите свързват координатора с партньорите.
Накратко на български
Метаболизмът на скелетните мускули и регулаторът AMPKalpha2 определят как стволовите клетки се сливат с мускулните влакна. Разбирането на този процес помага за по-доброто лечение на пациенти с метаболитни заболявания, водещи до мускулни патологии.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Metabolic regulation of reciprocal signalling between skeletal muscle cell types
Maintenance of skeletal muscle quantity and quality is crucial for healthy aging, and is facilitated by a remarkable tissue plasticity. Muscle-resident stem cells (MuSC) provide an important contribution to this plasticity by differentiation and subsequent fusion with the myofiber – a process called myonuclear accretion. The progression of this process is characterised by distinct MuSC metabolic requirements, and seems to depend on the myofiber metabolic state. We therefore anticipated a role of metabolism – and specifically, the metabolic regulator AMPKalpha2 – in myofiber to the MuSC signalling, directing MuSC fate towards myonuclear accretion. A better understanding of the process of myonuclear accretion and its regulation will be important to better understand disease aetiology and pathophysiology and will contribute to a better treatment (e.g., by AMPK activators) of patients with patient with (metabolic) diseases leading to muscle pathology that may be caused by impaired myonuclear accretion. The overall objectives of the project constitute a ‘proof of principle’, ‘target identification’, and ‘target validation’.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Maintenance of skeletal muscle quantity and quality is crucial for healthy aging, and is facilitated by a remarkable tissue plasticity. Muscle-resident stem cells (MuSC) provide an important contribution to this plasticity by differentiation and subsequent fusion with the myofiber – a process called myonuclear accretion. The progression of this process is characterised by distinct MuSC metabolic requirements, and seems to depend on the myofiber metabolic state. We therefore anticipate a role of metabolism – and specifically, the metabolic regulator AMPKalpha2 – in myofiber to the MuSC signalling, directing MuSC fate towards myonuclear accretion. We explore this in three aims, that constitute ‘proof of principle’, ‘target identification’, and ‘target validation’. To achieve these aims, we ensure a two-way transfer of knowledge by combining my Cre/LoxP-based cell system, with the host lab’s primary MuSC isolation. These combined technologies also provide a platform to study myonuclear accretion in the context of other molecular targets and diseases. Furthermore, we will initiate an interdisciplinary collaboration to perform integrative phosphoproteomics and metabolomics, and get a unique insight in the myofiber to MuSC signalling. This will provide AMPKalpha2-targets that will be validated using advanced mouse models established at the host lab, and provides leads for research after the fellowship. Results will be communicated to a scientific and non-scientific audience by publication in scientific journals, conference presentations, via Twitter, workshops and open days. Since the host lab is at the forefront of myogenesis research, it will provide me with an ideal environment to improve my scientific network, and receive the relevant technical and personal training. Together with the innovative nature and interdisciplinarity of the project, this will give me the unique opportunity to reach professional maturity both during and after the fellowship.
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITE LYON 1 CLAUDE BERNARD · Villeurbanne CedexКоординаторФранция
Връзки
Данни: CORDIS, © Европейски съюз