LectiNet · Understanding Lectins' network language with chemical tools: new insights for immunological purposes.
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2021-03-01 → 2025-12-04
- Финансиране от ЕС
- 275 561 €
- Участници
- 2
- Схема
- MSCA-IF
Линиите свързват координатора с партньорите.
Накратко на български
Дендритните клетки и техните рецептори се изследват чрез специални синтетични полимери, за да се разбере как те активират имунния отговор. Това помага за създаването на по-безопасни и прецизни ваксини и имунотерапии, подходящи за различни групи хора.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Understanding Lectins' network language with chemical tools: new insights for immunological purposes.
Problem/Issue Being Addressed: Dendritic cells (DCs) are the most potent antigen-presenting cells (APCs), capable of priming T-cell-mediated immune responses. They express numerous endocytic receptors on their surface that significantly influence the quality and magnitude of immune activation. However, a comprehensive molecular understanding of how to strategically co-engage these receptors to modulate immunity is still lacking. The LectiNet project addresses this knowledge gap by developing a library of over 50 synthetic, structurally defined polymers specifically designed to systematically evaluate the co-engagement of DC surface receptors and its impact on DC maturation, activation, and functional reprogramming. Importance for Society: The ability to finely tune dendritic cell activation and steer immune responses is critical for the rational design of next-generation vaccines and immunotherapies. Tailoring immune activation is particularly important to meet the needs of different population groups, including children, the elderly, and immunocompromised individuals. Insights gained from this project could significantly advance the fields of personalized medicine and public health by enabling the creation of safer, more effective, and more precisely targeted vaccines and adjuvants. Overall Objectives: The primary objective of LectiNet is to explore dendritic cell receptor co-engagement using synthetic ligands and to decipher the complex combinatorial "language" that governs DC responses. By systematically dissecting these receptor interactions, the project aims to uncover design principles for modulating cellular immunity, ultimately enabling the development of more precise and effective immunotherapeutic strategies.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Dendritic cells (DCs) are the most potent antigen-presenting cells due to their ability to prime T-cell immune responses. The numerous endocytic transmembrane receptors located on their surface can recognise and process endogenous and exogenous antigens. Despite DCs being efficient sentinels, pathogens, unfortunately, in some cases can evade their guard, and cause viral, bacterial infections, and cancer. The DCs mechanisms behind the lack or the presence of an immune response are not fully understood. Chemistry offers powerful tools to prepare synthetic antigens, mimicking the natural one. Synthetic antigens can, not only be exploited to disclose the relationship between the antigen chemical structure and its processing by the immune cells but also used to train the immune system to fight pathogens. The overall aim of LectiNet is to reveal how cooperative engagement of human C-type lectin receptors (CLRs) on DCs surface influences antigen internalisation, trafficking, and presentation. This will be achieved by targeting CLRs with heterogenous multivalent polymers and analysing DC signaling and antigen routing. LectiNet hence will disclose multitarget polymers as vectors to selectively deliver antigens through DCs following a pre-designed pathway to fight viral infection and cancer. In this global fellowship, I will benefit from the joint supervision of Professor Laura L. Kiessling from MIT and of Professor Paul V. Murphy from NUIG. LectiNet will provide me an excellent training to complement my current knowledge in synthetic chemistry, with immunology cell biology and polymer chemistry, placing me in a unique interdisciplinary area in the European research scenario. LectiNet will explore novel delivery strategies of vaccines for infectious disease and cancer and provide novel insights into the role of CLRs co-engagement.
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITY OF GALWAY · GalwayКоординаторИрландия
- MASSACHUSETTS INSTITUTE OF TECHNOLOGY · CambridgeСъединени щати
Връзки
Данни: CORDIS, © Европейски съюз