H2020Индивидуална стипендия2020–2022

MultiStem · Multifunctional polymer scaffolds for stem cell differentiation

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2020-09-01 → 2022-08-31
Финансиране от ЕС: 224 934 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Полимерни 3D структури с електрически и оптични свойства се използват за управление на развитието на стволови клетки. Тези системи помагат да се разбере как средата в човешкото тяло влияе върху растежа и специализацията на клетките.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Multifunctional polymer scaffolds for stem cell differentiation

A variety of factors are known to direct cell growth and differentiation. Although, the role of biochemical and mechanical cues in cell growth and differentiation are now relatively well understood, the role of electrical cues in cell development remain poorly understood. Recently, with the advent of functional conducting materials with modular properties that are easy to fabricate, it has become practicable to interface live cells with conducting materials in a more biomimetic fashion. Three-dimensional (3D) bioelectronic devices proposed to bridge the dimensionality mismatch between 2D/static electronics and 3D/dynamic biology, comprising a versatile platform for hosting and monitoring cells. These highly biomimetic systems can more accurately represent native tissues thanks to mimicry of biochemical, mechanical, and electrical cues. Stem cells take their cues from their environment and surroundings. A reliable platform that mimics accurately the human body environment, would be an invaluable tool in stem cell research. In general, tissue engineering has benefitted enormously from different materials used to create scaffolds to grow cells in 3D, however, only few studies report the development of 3D tissue-like structures that exhibit multifunctional properties (e.g. electrical and optical). Objectives - Fabrication of 3D-polymer scaffolds, mimicking the human body environment, with electrical and optical properties. - Development of healthy stem cell cultures within the scaffolds and being able to monitor their activity - Control the proliferation and differentiation of stem cells by taking advantage of the scaffold’s properties, i.e. by using electrical or optical stimulating pulses - Generation of a vast library of experimental data on how optical or electrical cues influence stem cells differentiation

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The field of bioelectronics devices that can translate ionic signals in our bodies into electronic signals, is one of the most remarkable success stories of science and engineering over the last decades. Although such devices have been lifesavers (i.e. pacemakers, glucose meters), recent discoveries are about to change the entire pharmaceutical industry. Organic bioelectronics, devices based on biocompatible polymers, opening new horizons in biomedical engineering. Recent developments in 3D materials and devices show a tremendous potential to deliver human-like platforms for tissue growth, however, these devices are still in their infancy. This project aims to take a fundamental approach to designing composite materials with electrical and optical properties that may be used for a multitude of applications in biomedical engineering. The project proposes the realization of 3D multifunctional scaffolds for stem cell control by blending optically and electrically active biocompatible polymers. Beginning with films, to understand mixing and properties, the project will gain insight into how these materials may be used for biological applications. Subsequently, the materials will be prepared in 3D formats and used to host stem cells. The multifunctional properties of the proposed scaffolds will be used to determine the effect of electrical and optical cues on stem cell differentiation. Stem cells play a key role in tissue engineering medicine as they have already proven effective in developing new treatments. These highly biomimetic platforms and the fundamental knowledge produced in this project will be an invaluable tool to further progress with stem cell research towards therapeutic goals. As such, the outcomes of this proposal can, in the short term, benefit the field of organic bioelectronics by providing fundamental knowledge and a novel platform for a facile control of cell function and in the long term, can impact the global need for better treatment of diseases.

Оригинален текст от CORDIS (на английски).

Участници

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE · CAMBRIDGEКоординаторОбединеното кралство