H2020Индивидуална стипендия2021–2022

LADENTHER · LAser DEvelopment of Nanotools for quantum-based THERapy

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-01-01 → 2022-12-31
Финансиране от ЕС: 144 981 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Специфични наноинструменти и ултрабързи лазери се разработват за диагностика и терапия на сърдечно-съдови и онкологични заболявания. Тези неинвазивни квантови техники могат да подобрят здравето на хората и да намалят икономическите загуби от дълготрайното отсъствие на болните от работа.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

LAser DEvelopment of Nanotools for quantum-based THERapy

This project is devoted to the development of novel approaches that can be further implemented in the field of biomedicine in order to make new strategies of the diagnostic and therapy of cardiovascular and oncologic diseases being one of the most serious problems in the world according to the World Health Organisation (WHO). Finding new ways of the therapy of the aforementioned diseases leading to high excess mortality every year also significantly affecting economical aspects of our life is a very challenging scientific task around the world. The corresponding research performed in the framework of this project is a long-term scientific study requiring deep knowledge and understanding of the occurred physical, chemical and biological processes due to the high energy laser irradiation and statistical analysis of the obtained experimental data. In order to achieve the planned aims by solving corresponding issues, the last achievements in the fields of ultrafast laser and nano-technologies together with the expertise of bioengineers should be combined to have the synergy of these scientific directions. The overall objectives of the project are to build a base for future generation medicine by performing a fundamental research for further development of non-invasive quantum based techniques being able to solve crucial issues of the human health that will further positively affect economical aspects by decreasing the downtime, which can extremely affect the worldwide economics as it could be seen during COVID-19 epidemiological situation.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The cardiovascular diseases are among most serious health problems of modern human society. Despite various advanced therapeutic, pharmaceutic and surgical methods of their treatment, significant improvement of human health has not been reached yet due to insufficient efficiency of these methods, side effects, soreness and long recovery. Hence, searching for novel approaches for both diagnostics and treatment of the diseases is of highest importance.This proposal will explore a new approach based on combining latest achievements in laser- and nano-technologies. Contamination-free multi-component nanoparticles with novel properties (efficient light absorption at specific wavelength ranges, enhanced photoluminescence for detection, minimal cytotoxicity and biocompatibility, etc.) will be synthesized by ultrafast laser irradiation of materials in aqueous environment. They will be tested as nanotools for treating actions on biological objects (model systems provided by biologists) for dissolving thrombus and cholesterol and for fatigued muscles recovery. The nanoparticles will be injected to the model systems (simulating problematic blood vessels and overexpressed muscles) and activated by ultrafast lasers tunable in mid-IR spectral range to make laser action gentle but effective with a deep penetration to bio-tissues. Irradiation will be performed in single- and multicolor modes to inspect capabilities for nanoparticle activation. The results of nano-phototherapy will be analyzed with assessment of its efficiency. The detailed protocols of nano-phototherapy will be prepared to continue these studies with biologists in-vivo after the project implementation. Outcomes of this proposal will bring new knowledge on the prospects of non-invasive therapy of cardiovascular problems that will have a positive impact on both fundamental science and bio-medicine in the European area. Implementation of this research will enable me to become a recognized expert in the field.

Оригинален текст от CORDIS (на английски).

Участници

FYZIKALNI USTAV AV CR, VVI · PRAHA 8КоординаторЧехия