H2020Индивидуална стипендия2020–2022

VIBRiOD · VIrus and BacteRia In Oral Disease: the EBV model in periodontitis

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2020-05-01 → 2022-04-30
Финансиране от ЕС: 196 708 €
Участници: 1
Схема: MSCA-IF-EF-CAR

Линиите свързват координатора с партньорите.

Накратко на български

Връзката между вируса Епстайн-Бар, вредните бактерии и имунната система при пародонтита се анализира чрез проучване на клетъчните процеси в устата. Разбирането на тези механизми помага за развитието на по-ефективни терапии срещу това разпространено заболяване.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

VIrus and BacteRia In Oral Disease: the EBV model in periodontitis

• Periodontitis is an infectious/inflammatory disease that destroys the tooth-supporting apparatus leading to teeth loss. It is also associated with 50 systemic diseases & cancers. Thus, the development of effective therapies requires deeper insights into the etiopathogenesis of periodontitis. • Periodontitis is 1 of the most prevalent human diseases, severe periodontitis being the 6th most common disease, with an overall prevalence of 11.2% & 743 million people affected. The total economic impact represents 442 billion USD. Obviously, periodontitis represents a major global health problem with significant social & economic impact. The results of the VIBRiOD have the potential to contribute to the advancement of periodontitis research & its ultimate control. • VIBRiOD was focused on the etiopathogenesis of periodontitis based on synergies between Epstein-Barr virus (EBV), pathogenic bacteria & human immune response. The objectives were: 1. Detect the EBV infection during periodontitis & establish the relationship to dysbiosis; 2. Understand the relationship between EBV, immune responses & dysbiosis; 3. Characterize the phenotypic & immune properties of infiltrated EBV+ cells; 4. Study the effects of healthy & pathogenic biofilms on EBV viral replication.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Periodontal disease, conditions that affect the structures surrounding the teeth, is the most common disease of mankind (listed #1 in 2001 Guinness World Records). The total economic impact of periodontal disease represents the major component of the $442 billion direct and indirect expenditures of oral diseases incurred worldwide in 2010. Periodontal disease can lead to tooth loss, causing aesthetic effect as well as affecting chewing and speech. Beyond oral health, it is associated with systemic diseases and even with cancer risk. Obviously, periodontitis represents a major global health problem with significant social and economic impact. Development of effective therapies, therefore, requires deeper insights into the etiopathogenesis of the periodontal disease. The focus has traditionally been that pathogenesis occurs when the balance between the oral microbial biofilm and the host is lost, owing to dysbiosis and immune overreaction of the host to microbial presence. However, bacterial-host interaction alone does not adequately explain the clinical features of the disease. Recently, a new paradigm was proposed in pathogenesis involving a viral and bacterial combination to promote long-term chronic inflammatory disease. The project VIBRiOD will be focused on the etiopathogenesis of periodontitis based on Epstein-Barr virus (EBV)–pathogenic bacterial biofilm–human immunity response synergies. Specifically, the VIBRiOD aims to understand 1) EBV behaviour during periodontitis and relationship to dysbiosis, 2) bidirectional interaction of dysbiosis and EBV activation, 3) tridirectional relationship of dysbiosis, EBV activation and host immune response. The multidisciplinary nature of the project is strong, involving a combination of classic to modern approaches of microbiology, molecular biology, immunology and virology. The results have the potential to contribute to the advancement of periodontitis research and ultimate control of the disease.""

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITE COTE D'AZUR · NiceКоординаторФранция