H2020Индивидуална стипендия2021–2023

ROCHESTER · Quantification of Free and Bound Water Concentrations in Human Cortical Bone Employing Hybrid Hard-tissue MRI: Towards Comprehensive Osteoporosis Assessment

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-05-01 → 2023-09-30
Финансиране от ЕС: 224 934 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Количеството на свободната и свързаната вода в човешката кортикална кост се изследва чрез специализиран магнитен резонанс. Това помага за по-точна оценка на качеството на костите при остеопороза.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Quantification of Free and Bound Water Concentrations in Human Cortical Bone Employing Hybrid Hard-tissue MRI: Towards Comprehensive Osteoporosis Assessment

Specific Objectives: 1. Literature review on the cortical bone water: • Extensive studies were carried out to understand role of MRI to detect cortical bone water in the assessment of cortical bone quality. 2. Novel methodologies to acquire cortical bone MRI: • UTE sequences at 7T preclinical MRI (Bruker) were implemented and acquired: Image #1 Image #2 3. Verification of the novel imaging method: • Quantification was carried out to show if the new imaging method enables constructive signal for the measurement: Image #3 Image #4 • Analysis of the new images were developed using new generation of deep learning techniques. Results are planned in two different categories: i. T2-map (Variable TEs); Finding notion of the three proton pools, ii. T1-map (Variable FAs); Finding notion of porosity-related signal changes / Relaxometry. • Two different estimation schemes must are finalized for accurate parameter mapping i. Mutual estimation of the three proton pool from 7T data (ways to consider minerals with MRI), ii. QSM / phase quantification and mineralization data from uCT (uCT data to be acquired). 4. Clinical biomarker achieved: • Multi sample acquisition and related data analysis to be carried out.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Osteoporosis weakens bones and increases the risk of unexpected fractures. Worldwide, it causes over 8.9M fractures annually. Cortical bone consists of 3 major parts; minerals, organic matrix and water. Bone Mineral Density (BMD) is the most widespread marker to assess bone quality. There is recent evidence, however, that bone mineralisation offers only an incomplete view of bone quality. In turn, bone water (including free and bound water molecules) does convey richer information about bone quality by probing both bone porosity and the organic matrix.We propose to develop a novel diagnostic imaging technique based on Magnetic Resonance Imaging (MRI) that offers a comprehensive assessment of cortical bone quality and osteoporosis. The quantification of free and bound water molecules in cortical bone will be done in vivo as their alternation are potential biomarkers of the cortical bone quality. We will use hybrid hard-tissue MRI to capture information from short transverse-relaxation time (T2) species. We will develop MRIstrategies that will go beyond the state-of-the-art in imaging bone tissue (herein referred to as “hard-tissue MRI” employing novel pulse sequences from the ultra-short echo-time (UTE) family. A key novelty lies in the hybridisation of UTE/short echo time (STE) acquisitions. By solving a set of coupled equations derived from these acquisitions using machine-learning techniques, we will define new quantitative imaging biomarkers associated with cortical bone free and bound water concentrations.The biomarkers will improve diagnosis of osteoporosis and alleviate its burden on healthcare systems (€37Bn cost to EU in 2010). It offers further potential in assessing bone development in pediatric imaging where ionizing and invasive methods cannot be employed. The project brings together expertise in bone MRI from a senior incoming fellow with the world-class expertise in biomedical image analysis and bone research as well as a pioneer centre in clinical.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITY OF LEEDS · LeedsКоординаторОбединеното кралство