HippoFronThal · Role of midline thalamic neurons during memory related hippocampal and cortical network activity
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2021-01-20 → 2024-12-09
- Финансиране от ЕС
- 235 191 €
- Участници
- 2
- Схема
- MSCA-IF
Линиите свързват координатора с партньорите.
Накратко на български
Неврони в средната част на таламуса при мишки се изследват, за да се разбере как сигнали за глад или страх влияят върху паметта и поведението. Това помага да се разбере как мозъкът обединява информация от тялото и средата, за да избере подходяща реакция.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Role of midline thalamic neurons during memory related hippocampal and cortical network activity
In everyday life, our behavior is primarily driven by our motivation and need. Yet, at the same time, it is constrained by external conditions, like the presence of a threat. Our brain has to make decisions in many conflicting situations throughout our life and it constantly learns and re-evaluates what kind of behavior would be the best for us. Research in mice revealed an evolutionary conserved system of interconnected brain regions that is responsible for motivated behavior. A key component of this system is the midline thalamus, that collect information about the internal states and needs of the organism - like pain, hunger or fear -, but also communicates with brain areas that form memories and organize behavior. The aim of HippoFronThal is to understand how the midline thalamus contributes to motivated behavior. We particularly focus on how neurons in the midline thalamus cooperate and communicate with neurons in other parts of the brain. To explore this question, we combined multiple cutting-edge techniques to identify and monitor the activity of midline thalamic neurons in freely behaving mice during various types of behavior. The significance of this work would be to help better understand how the brain processes information coming from the body and from the environment and how it integrates them with existing memories in order to select appropriate behavior.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Emotional memories guide our social interactions, everyday decisions, and are indispensable for survival. However, malfunction of brain networks involved in emotional processing may lead to a variety of anxiety-related and other psychiatric disorders, harmful for the individual and a burden, even a threat, to society. Emotions are associated with generalized arousal, however, it is not well understood how arousal systems play role in emotional memory processing at the network level. HippoFronThal aims to investigate the role of a specific thalamic arousal system in emotional processing. The hippocampus and prefrontal cortex are the core of an evolutionary conserved distributed system for governing experience-based behavior. Previously we identified a molecularly specific neuronal population within the dorsal midline thalamus, which efficiently convey arousal to large parts of the forebrain. These neurons are uniquely connected to the hippocampal-prefrontal system, possessing a strategic position to modulate hippocampal-cortical information transfer. The specific goal of HippoFronThal is to investigate, how neuronal activity of the dorsal midline thalamus interacts with network activity of the hippocampal-prefrontal system during emotional processing. To accomplish this goal, I will utilize molecular-genetic approaches to ensure anatomical specificity, perform high throughput electrophysiological recordings with outstanding spatio-temporal resolution, apply optogenetics to cell-type specific circuit interrogation with high spatio-temporal specificity, and use ecologically relevant behavioral essays to examine thalamic involvement in innate and memory related emotional processing.HippoFronThal will improve our understanding in how arousal circuits interact with memory circuits in the brain. These results might help clinicians to target specific neuronal population or mechanisms in order to treat anxiety-related disorders in humans.
Оригинален текст от CORDIS (на английски).
Участници
- HUN-REN KISERLETI ORVOSTUDOMANYI KUTATOINTEZET · BUDAPESTКоординаторУнгария
- NEW YORK UNIVERSITY · NEW YORKСъединени щати
Връзки
Данни: CORDIS, © Европейски съюз