H2020Индивидуална стипендия2020–2023

SkinOptima · Link Skin Morphology and Vasculature with Diseases using Optical Imaging

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2020-12-01 → 2023-10-31
Финансиране от ЕС: 270 349 €
Участници: 3
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Връзката между кръвоносните съдове в кожата и различни заболявания, като хроничната венозна недостатъчност, се анализира чрез 3D оптично изображение. Това помага за по-точна диагностика на кожните проблеми чрез количествено проследяване на промените в съдовете.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Link Skin Morphology and Vasculature with Diseases using Optical Imaging

The major problem being addressed is whether there is a link between cutaneous vasculature and skin diseases. So far, many research groups noticed that there are skin vasculature changes when there are skin diseases, but how to link the vasculature with diseases remain an open topic due to the lack of proper methods. This project aims to explore the use of optical coherence tomography angiography (OCTA) and photoacoustic tomography (PAT) to answer this question. Since OCTA can visualize the superficial plexus of human cutaneous vasculature and PAT can image the deep plexus of human cutaneous vasculature, combining OCTA and PAT should be able to give people a method to visualize in 3D the complete human cutaneous vasculature. When the whole vasculature is extracted from different patients, we can then analyze the vasculature in a quantitative manner so that a parametric approach can be taken to help accurate diagnosis of skin diseases directly using skin vasculature information. In this action, a cohort of 66 human subjects were recruited and imaged using the OCTA machine developed within this project. These human subjects consisted of people suffering from various stages of chronic venous insufficiency (CVI). The wide span from healthy subjects to skin ulcer subjects generated a complete spectrum of the disease progression. OCTA imaging was applied in a painless and non-invasive manner. All the images were then quantitatively analyzed. It was noticed that, along with the progression of the disease, skin vasculature showed different patterns. The quantitative analysis done in a parametric way was then confirmed by clinicians. This is the first study when OCTA was used for this type of phlebological disease. The microvasculature resolved using OCTA gave the clinicians a new way to help triage and treat skin diseases. Because CVI is affecting a huge portion of the elderly population, whereas OCTA scan is completely painless and non-invasive, the work carried out in this action has the potential to provide a new tool in the phlebology diagnosis procedure. On top of OCTA, a PAT system was also developed and applied in clinical imaging. It was proven that with the help of PAT, the image penetration depth can be significantly enhanced. The combination of OCTA-PAT can therefore be used in wider applications in dermatology in addition to phlebology.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

According the the Global Study of Diseases 2017, skin and subcutaneous diseases have increased rapidly in the past decade measured by the disability adjusted life years. However, there is still a lack of knowledge in many of these diseases, and the need for a novel method to study, diagnose and treat skin disease is ever-increasing. The current diagnostic tools, such as dermoscopy and biopsy, are either not sensitive enough or very invasive and time-consuming. Knowing that skin and subcutaneous diseases alter the cutaneous vasculature, SkinOptima proposes to use a multi-modal optical imaging method to extract the complete human cutaneous blood vessels in a non-invasive and in vivo manner. Then, the blood vessel network will be quantified in different perspectives. Using quantitative analysis of the vascular parameters, a link between three major skin diseases and their unique vascular patterns can be established. A lesion area determination algorithm will also be developed to help the dermatologists prepare skin cancer removal surgeries and monitor the treatment efficacy. This multi-modal approach involves two optical imaging modalities - optical coherence tomography (OCT) and photoacoustic tomography (PAT). OCT alone can extract tissue morphology for about 1 mm in skin. A functional extension of OCT, called OCT angiography (OCTA) is capable to extract the micro-vessels in the first millimeter in skin. PAT, on the other hand, can image skin blood vessels with a coarser resolution from 1 mm down to 5 mm below the skin surface. An imaging probe will be designed to combine these two modalities for patient imaging. To develop all the vessel extraction and vessel quantification algorithms, several types of skin phantoms will be 3D printed. In the end, about 150 patients will be imaged by the multi-modal system and the link between vasculature and diseases such as basal cell carcinoma, squamous cell carcinoma and dermatitis will be established.

Оригинален текст от CORDIS (на английски).

Участници

MEDIZINISCHE UNIVERSITAET WIEN · WienКоординаторАвстрия
SINGAPORE EYE RESEARCH INSTITUTE · SingaporeСингапур
UNIVERSITY OF WASHINGTON · Seattle WaСъединени щати