H2020Индивидуална стипендия2021–2023

SWEETENED HEARTS · Are non-nutritive sweeteners vascular-safe substitutes for added sugars?

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-09-01 → 2023-08-31
Финансиране от ЕС: 196 708 €
Участници: 1
Схема: MSCA-IF

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Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Are non-nutritive sweeteners vascular-safe substitutes for added sugars?

In an effort to address the increasing incidence of poor cardiometabolic health, leading health agencies around the world advocate the consumption of foods and beverages containing non-nutritive sweeteners as healthy alternatives to those containing added sugars. However, several epidemiological studies have reported significant, counterintuitive associations between the consumption of non-nutritive sweeteners and weight gain, an increased incidence of type 2 diabetes, and cardiovascular events (e.g. heart attacks). Additionally, mice studies indicate that non-nutritive sweeteners, like excess sugar, may have a direct role in the impairment of vascular reactivity; findings that raise serious concerns over the assumed physiological inactivity of non-nutritive sweeteners. Indeed, rather than helping improve cardiometabolic health outcomes, as promoted, consuming non-nutritive sweeteners may be as harmful to vascular and metabolic health as is excess sugar consumption; thus, contributing to one of the greatest, preventable burdens to health care systems, economies, and societies both in Europe and abroad. Considering this, the SWEETENED HEARTS study aimed to, for the first time in vivo, assess the effect of non-nutritive sweetener consumption on vascular and metabolic function in humans. As a result of the COVID-19 pandemic, the clinical research centre in which the project was hosted was instructed to redirect of 100% research resources to conducting clinical trials for COVID-19 vaccines. This delayed the implementation of the project and, as a consequence, data collection is still ongoing. Results from this study have the potential to indicate if non-nutritive sweeteners can contribute to the development of CVD, obesity and insulin resistance; findings that may encourage health authorities to revisit the regulatory status of non-nutritive sweeteners.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

In an effort to reduce the incidence of obesity, type 2 diabetes and cardiovascular disease, leading health agencies around the world are currently promoting the consumption of food and beverages containing non-nutritive sweeteners (NNS), advocating them as healthy alternatives to products sweetened with added sugars. As the harmful health effects of excess sugar consumption are often attributed to the high-energy content of added sugar, it has been assumed that NNS are physiologically inactive simply because they have little to no energy content. Recent evidence, however, demonstrates an increased risk in total and cardiovascular disease mortality in people consuming at least two NNS-sweetened beverages per day. While these findings are interesting, they are difficult to interpret as NNS are typically consumed more often by those whose cardiometabolic health is already compromised. Despite this, evidence from animal studies, including that delivered by our own consortium, indicate that NNS have the potential to disrupt normal metabolic and vascular function, events that are primary in the development of obesity, insulin resistance and cardiovascular disease. Indeed, rather than benefiting us, the impact of consuming NNS may be as bad on human health as the effects of excess sugar consumption. To bridge the findings from epidemiological and experimental research, this Standard EF will, for the first time in vivo, in humans, assess the metabolic and vascular effects of consuming NNS habitually; via a prospective, placebo-controlled, randomized, three-period crossover study. This research will also provide information about the role of type 1 sweet taste receptors (T1Rs), as well as oral sweet taste perception, in any potential NNS-mediated vascular/metabolic dysfunction. Ultimately, the findings from this research will inform policy makers about the safety of NNS, with the potential to lobby health authorities to revisit the regulatory status of these substances.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITE GRENOBLE ALPES · GrenobleКоординаторФранция