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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Докторантска мрежа2020–2025

SmartAge · Gut-brain-axis: Targets for improvement of cognition in the elderly

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2020-09-01 → 2025-02-28
Финансиране от ЕС
3 946 981 €
Участници
12
Схема
MSCA-ITN

Линиите свързват координатора с партньорите.

Накратко на български

Връзката между червата и мозъка при възрастните хора се анализира чрез процеси като възпаления и пропускливост на чревната стена. Това помага за откриването на нови начини за диагностика и подобряване на когнитивното здраве при деменция.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Gut-brain-axis: Targets for improvement of cognition in the elderly

Currently, no cure exists to prevent progression from mild cognitive impairment to dementia. This pressing societal challenge has long been understudied. SmartAge addressed this gap by exploring the gut-brain axis and its influence on cognition during aging, with the aim to identify novel diagnostic and therapeutic strategies. Concurrently, SmartAge responded to the growing demand for specialists in this interdisciplinary field. The main objectives were in short: • Investigate gut-brain interactions in aging via hypotheses on inflammaging, intestinal permeability, and immune responses. • Identify microbiome-based targets for diagnostic and therapeutic development to improve cognitive health. • Train early-stage researchers in designing and conducting lifestyle and nutritional interventions. • Educate a new generation of interdisciplinary scientists skilled in gut-brain communication in aging. Conclusion of the action: SmartAge effectively delivered on its dual mission: advancing scientific understanding of gut–brain interactions in aging and establishing a high-quality training environment for early-stage researchers. The project implemented an innovative and coherent research programme across multiple disciplines, resulting in a shared knowledge base, enduring collaborations, and capacity-building within and beyond academia. The structured integration of fundamental science, technology development, and translational perspectives ensured that SmartAge not only contributed to answering key research questions but also positioned its outputs for future exploitation in clinical and societal contexts. The consortium maintained strong coordination, met all planned milestones, and fostered a culture of open communication and knowledge exchange. Through its inclusive outreach activities, SmartAge also promoted public engagement with brain and gut health, supporting a broader impact beyond the scientific community. As a result, the project leaves behind a legacy of new insights, validated platforms, trained experts, and stakeholder networks that will continue to drive innovation in cognitive aging research.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

In Europe, the population is aging. The age-associated decline in cognitive functions represents a serious social and medicalproblem. Recent studies show that changes in lifestyle such as physical activity and nutritional interventions – even late inlife –are beneficial for cognition. The microbiome in the gut is a central effector in the maintenance of brain plasticity andtherefore represents a promising target as well as sensor for interventions that aim to improve cognitive ability in the elderly.Detailed and concise scientific investigations of gut-brain interactions, in particular in the elderly, are limited. Such studiesrequire a multidisciplinary approach and a combination of experts from various fields. The aim of our network is to train anew generation of young scientists within a multidisciplinary consortium. The ESRs will engage in individual and welldefined, jointly supervised research projects, securing excellent career perspectives and employability. By enabling ESRs todesign and conduct studies in this economically and socially important field, SmartAge will elucidate the role of themicrobiome-gut-brain axis in aging and its impact on cognition. SmartAge will apply a translational approach combininganimal and human studies, nutritional and life style interventions, cognitive tests, brain imaging, cutting edge OMICS andsystems biology as well as fecal transfer as proof of principle to identify key regulators of gut-brain communication with theaim to develop microbiome-based therapies. An expert team of scientists from both academia and industry such as clinicians, psychologists, nutritionists, biotechnologists and bioinformaticians will closely collaborate to strengthenmicrobiome research in aging which will have a direct impact on cognitive health in Europe. Specialists for publiccommunication outreach will ensure effective and efficient transfer of outcomes to policy makers and into the everyday life ofthe European population.

Оригинален текст от CORDIS (на английски).

Участници

Връзки

Данни: CORDIS, © Европейски съюз