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H2020Докторантска мрежа2021–2025

COL_RES · Colonization resistance: training and research towards microbiome derived solutions to foodborne disease

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2021-03-01 → 2025-02-28
Финансиране от ЕС
2 186 997 €
Участници
6
Схема
MSCA-ITN

Линиите свързват координатора с партньорите.

Накратко на български

Чревните бактерии и механизмите, чрез които те спират патогени като салмонела и ешерихия коли, са в центъра на анализа. Разбирането им помага при създаването на пробиотици и лекарства за предпазване от хранителни инфекции, които yearly заразяват милиони хора.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Colonization resistance: training and research towards microbiome derived solutions to foodborne disease

The gut microbiota provides a significant barrier to foodborne infection through a mechanism called colonization resistance. However relatively little is known about particular bacterial species in the GI tract that contribute to colonization resistance or the mechanisms by which the exclusion of particular pathogens occurs. Understanding colonization resistance and identifying the key bacterial species involved will inform the design of rational probiotic and pharmaceutical strategies to prevent or treat foodborne infection. Every year there are an estimated 600 million cases of foodborne infection globally with 420,000 deaths. In the WHO European Region approximately 23 million people fall ill annually from foodborne infection with an estimated 4654 deaths. The impacts for society both globally and locally within the European Region, are clearly highly significant. The overall objectives of COL_RES are to examine the mechanisms by which the gut microbiota protects against serious foodborne pathogens (Salmonella, E. coli, Listeria, Citrobacter rodentium and Campylobacter) in order to identify potential probiotics that can protect against individual or multiple infectious agents. The network employed a systems biology-based approach by exploiting a variety of research models at world-leading laboratories, combined with metabolomics, bioinformatics and phage therapeutics to generate multi-omics data that has uncovered mechanisms by which the gut microbiota protects against specific foodborne pathogens and has informed the development of model experimental systems. Throughout the collaborative research programme COL_RES provided state-of-the-art training for 8 early-stage researchers preparing them for problem solving and entrepreneurial roles in industry and society and underpinning cutting-edge research in infectious disease in the EU. All 8 ESRs have completed (or are due to complete) their PhD studies.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The COL_RES network comprises a world-leading group of investigators that will investigate the mechanisms by which the gut microbiota protects against serious foodborne pathogens (Salmonella, E. coli, Listeria, Citrobacter and Campylobacter) and lead to the identification of next generation probiotics that can protect against multiple infectious agents. Through intersectoral industry-academia secondments the network will provide state-of-the-art training for early stage researchers (ESR) preparing them for problem solving and entrepreneurial roles in industry and society and underpinning cutting-edge research in infectious disease in the EU. Food and water borne diseases cause 23 million illnesses in the European region with 5000 deaths per annum and represent an increasing challenge to the health of the EU and global population. Through studying different pathogens using shared approaches the COL_RES network will undertake a network-wide approach to identify overlapping mechanisms by which members of the gut microbiota provide a barrier to infection through the phenomenon of Colonization Resistance. The work will utilise a systems-based approach by exploiting existing research models at world-leading laboratories combined with phageomics, metabolomics and bioinformatics to generate multi-omics data that will uncover both pathogen-specific and shared mechanisms by which the gut microbiota protects against foodborne pathogens. The work will inform the selection and testing of specific next-generation probiotic candidates that can protect against foodborne infections, with potential for further development by our industry partners. Thus, the network will enhance training through world-leading research via cross-sectoral industry secondments in an actively entrepreneurial environment.

Оригинален текст от CORDIS (на английски).

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Данни: CORDIS, © Европейски съюз