HYPERBOOST · Creation of advanced cancer treatment planning to boost the effect of Radiotherapy by combining with hyperthermia, heating the tumor.

Creation of advanced cancer treatment planning to boost the effect of Radiotherapy by combining with hyperthermia, heating the tumor.

Hyperthermia (HT), heating tumors to temperatures of 40-44°C, is an oncological treatment used in combination with radiotherapy (RT) and chemotherapy to enhance their efficacy. Clinical effectiveness of HT has been demonstrated in randomised studies and HT is currently applied for many clinical indications, like cervical cancer and recurrent breast cancer. Clinical results can be further improved as application of HT with well-controlled tumor temperatures and optimal timing and sequence realising full synergy of RT+HT is challenging. Optimal HT delivery requires accurate planning, moreover preclinical research has shown that many mechanisms are responsible for the therapeutic effect of HT, all presumably with a different temperature-effect relationship and with different optimal timing between RT and HT. Optimisation of clinical RT+HT treatments therefore requires a quantum leap in understanding and in clinical application. Scientific objective of this multidisciplinary project with contributions from all sectors and disciplines (biology, physics and oncology) is to combine training and research into the synergistic molecular mechanisms responsible for the therapeutic effect of HT on RT with the development of a versatile and innovative planning platform which utilises biological knowledge to achieve optimal patient-specific treatment delivery and ultimately application in a clinical registration study in a network of European centres implementing this treatment planning software to ensure optimal treatment delivery. The major objective of Hyperboost is therefore to train a new generation of creative and entrepreneurial professionals with the skills and expertise to coordinate, develop, apply and optimise advanced multi-modality cancer treatments. HYPERBOOST will also develop an advanced personalised treatment planning platform for hyperthermia based on extensive (pre)clinical data. The key aims of the HyperBoost project are to: 1. Train and equip early stage researchers with transferable, multi-disciplinary skills essential in high-end biomedical engineering, clinical hyperthermia and translational oncology (WP2) 2. Obtain and validate new insights into clinical working mechanisms of hyperthermia (WP3) 3. Translate preclinical and clinical results (WP3, WP5) into mathematical relations and treatment planning models (WP4) 4. Apply novel treatment planning models for personalised treatment (WP4) to improve the efficacy of clinical treatments (WP5) 5. Initiate, stimulate and profit from multidisciplinary cross-pollination between the disciplines involved in hyperthermic oncology (WP3-5) 6. Consolidate and expand the European infrastructure and industry for hyperthermia research and clinical application (WP 2-6)

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз