H2020Индивидуална стипендия2021–2023

FlyTryp · Investigating susceptibility to trypanosomatid parasites using Drosophila melanogaster as a model

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-09-01 → 2023-09-30
Финансиране от ЕС: 224 934 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Генетиката на податливостта към паразити от групата на трипанозоматите се изучава чрез модела на плодовата муха Drosophila melanogaster. Това помага за по-доброто разбиране на взаимодействията между гостоприемник и паразити, които влияят върху здравето на хората, земеделието и опазването на природата.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Investigating susceptibility to trypanosomatid parasites using Drosophila melanogaster as a model

Host-parasite interactions play an important role in shaping wild and domestic animal populations that, in turn, influence many aspects of human life, such as agriculture, epidemiology and conservation. In particular, vector-borne diseases have a profound impact on human health, and here this project studies trypanosomatid infection in insects. Trypanosomatids are a large group of organisms that are the cause of several diseases in vertebrate hosts, transmitted by biting insects. Most of these insect vectors are challenging to study under laboratory conditions, limiting progress on understanding the genetics of these host-parasite interactions. The project challenges developing a trypanosomatid-host model in the fruit fly, Drosophila melanogaster - a proven model for experimental studies with a well-established molecular, genetic and genomic toolkit and a vast of prior knowledge of its biology. The overall objective of the project Is to investigate the genetics of fly susceptibility to trypanosomatid parasite infection at the molecular and genetic level using the molecular and genomic information available for Drosophila.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

One of the specific United Nations Sustainable Development goals is to end epidemics of neglected tropical diseases by year 2030. Some of the most devastating of these diseases are caused by trypanosomatid parasites that are transmitted to humans via the bites of infected insects from the order Diptera (Flies). While most natural fly vectors pose a challenge to study under laboratory conditions, Drosophila melanogaster, with its well-established molecular, genetic and genomic toolkit and a vast amount of prior knowledge of its biology, is a proven model for experimental studies. Because D. melanogaster is host to several natural parasites that belong to the trypanosomatid group, it can also serve as a model for studying fly-parasite interactions. In this project, we propose to take advantage of the Drosophila melanogaster Genetic Reference Panel (DGRP) to investigate the genetic basis of fly susceptibility to trypanosomatid infection. First, we will perform a genome-wide association study (GWAS) for natural susceptibility to trypanosomatid parasite using a well-developed DGRP mapping resource to map genetic variation in susceptibility. Further, we will also test for differences in gene expression associated with infection susceptibility, using RNA sequencing, and validate the candidate genes identified with GWAS and RNA sequencing. Together, along with the well-annotated Drosophila genome, these data will reveal functional pathways affecting susceptibility to trypanosomatid infection. The established Drosophila-trypanosomatid system can serve as a functional model for insect-vectored diseases in medically and economically relevant species of Diptera.

Оригинален текст от CORDIS (на английски).

Участници

THE UNIVERSITY OF LIVERPOOL · LIVERPOOLКоординаторОбединеното кралство