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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Докторантска мрежа2021–2025

INFLANET · Training European Experts in Inflammation: from the molecular players to animal models and the bedside

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2021-03-01 → 2025-05-31
Финансиране от ЕС
3 977 117 €
Участници
13
Схема
MSCA-ITN

Линиите свързват координатора с партньорите.

Накратко на български

Хроничните възпаления се изследват чрез генетични анализи, животински модели и математическо моделиране. Това помага за по-доброто разбиране на болестите и ускорява откриването на нови противовъзпалителни лекарства.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Training European Experts in Inflammation: from the molecular players to animal models and the bedside

The high prevalence of chronic inflammatory diseases has major impacts on life quality and healthcare costs in western societies. Accelerating the pace of anti-inflammatory drug discovery is a formidable challenge. This requires a comprehensive understanding of inflammatory processes, allowing us to link the underlying genetic, molecular and cellular events to the physiological processes in inflamed tissues. The goal of INFLANET is to: (1) Understand how inflammatory signals are detected, integrated and propagated in an organism. (2) Elucidate the genetic bases of inflammatory disorders and inform therapeutic strategies. (3) Use cutting-edge intravital imaging strategies in animal models to study inflammatory processes, and anti-inflammatory drugs actions. (4) Develop original mathematical modelling tools to analyse the wealth of data generated, to inform disease model development, and to provide tools for physicians to understand the pathological basis of inflammatory disorders. An enthusiastic group of fifteen Marie Curie Research Fellows have been recruited between 2021 and 2023. During the 51 months of the project from 2021 to 2025, they have been trained through research, PhD enrolment in their respective institutions and via 5 central network-wide training events with physical presence and digital conferences. They addressed critical issues related to inflammation by developing complex models, identifying novel anti-inflammatory drugs and therapeutic targets, and effectively communicating their findings to a broad audience.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

INFLANET, with full support from academia and industry, will train 15 future scientific experts of inflammation through a combination of individual research projects, collaborative efforts, and interdisciplinary and intersectoral training. The prevalence of chronic inflammatory diseases in western societies is 5-7%, having a major impact on quality of life and healthcare costs. Accelerating the pace of anti-inflammatory drug discovery and deepening insights into drug actions poses a formidable challenge. This requires a comprehensive understanding of inflammatory processes, allowing us to link the underlying genetic, molecular and cellular events to the physiological processes in inflamed tissues. The ultimate goal of INFLANET is to provide innovative solutions for key bottlenecks in the inflammation field. To this end, we aim to:(1) Understand how inflammatory signals are detected, integrated by inflammasome platforms, and propagated into tissues (2) Take omics approaches to elucidate the genetic bases of inflammatory disorders and inform therapeutic strategies(3) Use cutting-edge intravital imaging strategies in animal models to study molecular and cellular mechanisms of inflammatory processes, and anti-inflammatory drugs actions(4) Develop original mathematical modelling tools to analyse the wealth of data generated, to inform disease model development, and to provide tools for physicians to understand the pathological basis of inflammatory disordersOur unique training approach will unite scientists from very different fields of biology, including structural biologists, bioimagers, immunologists, and geneticists, with mathematicians, programmers and modellers. Moreover, our intersectoral training will foster business thinking and entrepreneurship. Together, INFLANET will deliver a complete curriculum for the next generation inflammation scientists, mastering phenomenological understanding, medical imaging, high content screening and therapeutic strategies.

Оригинален текст от CORDIS (на английски).

Участници

Връзки

Данни: CORDIS, © Европейски съюз