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H2020Докторантска мрежа2021–2024

PEST-BIN · Pioneering Strategies Against Bacterial Infections

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2021-01-01 → 2024-12-31
Финансиране от ЕС
4 144 986 €
Участници
11
Схема
MSCA-ITN

Линиите свързват координатора с партньорите.

Накратко на български

Бактериалните инфекции се изследват чрез нови методи за диагностика, анализ на протеини и създаване на антибактериални повърхности за унищожаване на биофилми. Това е важно, защото антибиотичната резистентност се разпространява бързо и застрашава здравето на хората в целия свят.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Pioneering Strategies Against Bacterial Infections

The World Health Organisation (WHO) classified antibiotic resistance as one of the greatest threats to global health. Due to misuse and excessive consumption of antibiotics, anti-microbial resistance (AMR) in bacteria has expanded world-wide and is increasing at accelerating rates. Discovery of new antibiotics is not likely to turn the tide. The humanity clearly needs to pioneer new disruptive technologies to re-gain the upper hand in fighting bacterial infections. To address this issue, PEST-BIN is targeting three areas of science and technology development, corresponding to three scientific work packages in the project: 1) Diagnostics: Development of reliable, rapid, sustainable and cost-effective analytical techniques for comprehensive diagnostics and characterizations of infectious bacteria. 2) Infection mechanisms: Generation of proteomics datasets that are relevant, comprehensive and time-resolved from the perspective of infections and the use of a wide array of computational tools to extract relevant information about mechanism of infection from proteomics datasets. 3) Destroying bacterial biofilms: A new line of attack on biofilms: mobilizing players from two distant fields: nano-engineering of antibacterial surfaces and development of new antibiotics that can be conjugated with such surfaces for enhanced delivery to biofilms. Scientific advances are of course only one component of what PEST-BIN aims to deliver. Our other contributions are in training and enabling ESRs to become future leaders in this field, and strengthening the European capacity for interdisciplinary collaboration. Overarching strategic objectives of PEST-BIN are: 1) Develop the methods and the knowledge base for accelerated pioneering and implementation of innovative solutions for diagnosing and fighting bacterial infections. 2) Train a cohort of interdisciplinary experts who can effectively address challenges related to bacterial infections, working at the interface between academia and other sectors (industry, hospitals, public institutes). 3) Strengthen the European network of universities, companies, hospitals and institutes working on bacterial infections, to provide a dynamic platform for future training of ESRs.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The World Health Organisation named antibiotic resistance as one of the greatest threats to global health, predicting the advent of infections not responding to antibiotics. The humanity needs to pioneer disruptive technologies to re-gain the upper hand. To do so, PEST-BIN mobilized 5 universities, 3 institutes, a hospital and 5 private companies. We will fight infections with very diverse tools: from nano-engineering, antibiotic production, via proteomics-based diagnostics to big data analysis using artificial intelligence (AI). PEST-BIN will train ESRs in an interdisciplinary and intersectoral environment in these impact areas:1) Diagnostics: Current diagnostic tools fail to meet the clinical requirements for high speed, throughput, accuracy, cost and simplicity of use. PEST-BIN will develop infection diagnostic kits based on graphene, that will be functionalized by receptors capturing infection biomarkers. Our chips will contain only pure carbon and biodegradable polymers – zero environmental footprint. They will be used as “plug-and-play” disposable chips with a micro-SD jack.2) Infection mechanisms: MS proteomics has been extensively used to analyse infectious bacteria, but our understanding of infection mechanisms has not advanced much. PEST-BIN is taking two new directions: i) generate proteomics datasets more relevant, comprehensive and time-resolved and ii) use novel computational tools (based on AI) to analyse proteomics datasets. This will lead to new drug targets for development of antibiotics.3) Killing biofilms: Dense extracellular matrix prevents drugs from reaching bacteria inside biofilms. This limited exposure enhances development of antibiotic tolerance. PEST-BIN will engineer magnetic nanoparticles (directed by magnetic field), spiked with antibacterial graphene coating which will be loaded with antibiotics. Such molecular “nano-weapons” will physically penetrate biofilms and ensure sustained delivery of antibiotics inside biofilms.

Оригинален текст от CORDIS (на английски).

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Данни: CORDIS, © Европейски съюз