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H2020Докторантска мрежа2021–2025

Evomet · Deconstructing the evolution of metastasis

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2021-03-01 → 2025-02-28
Финансиране от ЕС
4 014 435 €
Участници
15
Схема
MSCA-ITN

Линиите свързват координатора с партньорите.

Накратко на български

Механизмите на метастазирането разглеждат как раковите клетки се разпространяват до други органи и се адаптират към новата среда. Разбирането на тези процеси помага за откриването на нови начини за противодействие на развитието на туморите и тяхната устойчивост към терапията.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Deconstructing the evolution of metastasis

Cancer continues to pose a major public health challenge in Europe, with more than 3.5 million people diagnosed annually. Metastasis—the spread of cancer cells to distant organs—is responsible for over 90% of cancer-related deaths. Despite its clinical importance, metastasis remains poorly understood, and treatment options for patients with metastatic disease are often limited and ineffective. One key barrier is the lack of comprehensive knowledge about how metastatic cells evolve, interact with their environment, survive therapeutic pressures, and eventually cause organ failure. EVOMET was launched to address this critical gap. As a Marie Skłodowska-Curie Innovative Training Network, EVOMET combined cutting-edge metastasis research with interdisciplinary, international training for 15 Early Stage Researchers (ESRs). The project applied an integrative approach, combining single-cell omics, in vivo models, functional genomics, and clinical data to dissect the fundamental mechanisms that govern metastatic progression and treatment resistance. The specific objectives of EVOMET were to: - Identify founding cancer cell clones that drive metastatic dissemination and therapeutic resistance, and characterize their molecular profiles; - Dissect tumour–stroma interactions and their role in shaping the metastatic niche; - Investigate the transition from metastatic latency to overt metastasis; - Elucidate the cellular dynamics, plasticity, and interconversions that drive metastatic outgrowth in distant organs. Conclusions of the action: EVOMET has successfully met its objectives, generating novel insights into metastasis biology and establishing new proof-of-concept models for therapeutic intervention. Tangible outcomes include 15 peer-reviewed publications (with more in preparation), development of innovative tools and methodologies (some with translational potential), and the training of a highly skilled cohort of ESRs who are now advancing into careers in academia, clinical research, and industry. The consortium has also laid the groundwork for continued collaboration through the follow-up doctoral network ADAPTMET, further amplifying the impact of the EVOMET initiative. By combining rigorous research with a structured and transferable training programme, EVOMET has made significant contributions to both cancer science and the training of future leaders in metastasis research—addressing a critical societal challenge with long-term implications for patient care and innovation in oncology.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Evomet aims to create a high-level training programme on the various aspects of metastasis evolution in order to provide young researchers with skills to become future leaders in the field. To this end, it is imperative to have a solid mentoring and training strategy, a state-of-the-art scientific approach, and a broad range of complementary soft skills. Collectively, these skills will be provided to each ESR through a series of events (local and network-wide) and initiatives that will allow ESRs to ensure smooth progress of their research projects and a successful career. Scientifically, Evomet has been designed to address an unmet medical need through leverage of basic science to impact drug development and, ultimately, improve how patients are managed. Scientific WPs tackling metastasis from a functional perspective have been defined. To metastasize, cancer cells must orchestrate diverse cellular functions to overcome the challenges inherent in the metastatic cascade (Cell Fate – WP1). These functions are also highly dependent on the interactions of the metastatic cell with the host immune system and tissue stroma (Environment – WP2). However, the kinetics of metastasis and, in particular, the mechanisms that regulate metastasis latency remain poorly understood (Latency – WP3). Mapping this complexity, examining patterns of clonal evolution, mechanisms of therapy failure, and pathways for expansion is central to defining new targets (Expansion – WP4). In summary, we are facing a fast-growing multidisciplinary area created from the aggregation of different fields that have problems communicating with each other. Evomet’s success builds on the strong relations between partners, the open exchange of ideas, state-of-the-art methodology, tools and equipment as well as the exploitation of synergistic opportunities between the network members, covering different perspectives and filling the gap between them, thus breaking the isolation between disciplines.

Оригинален текст от CORDIS (на английски).

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Данни: CORDIS, © Европейски съюз