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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Докторантска мрежа2021–2025

RAPTOR · Real-time Adaptive Particle Therapy of Cancer

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2021-03-01 → 2025-08-31
Финансиране от ЕС
3 967 111 €
Участници
13
Схема
MSCA-ITN

Линиите свързват координатора с партньорите.

Накратко на български

Протонната терапия се адаптира в реално време, за да се коригира планът за лечение, ако туморът или органите се изместят. Това позволява по-прецизно насочване на дозата към тумора и намаляване на страничните ефекти за пациентите.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Real-time Adaptive Particle Therapy of Cancer

Radiotherapy for cancer is usually planned before treatment starts and assumes the patient’s anatomy does not change. In real life, tumours and healthy organs can move or change shape between and during sessions. These changes may reduce treatment accuracy and increase side effects. RAPTOR set out to make proton therapy “adaptive”: updating the treatment plan using the patient’s daily images so that the right dose reaches the right place, every time. More precise treatments mean better tumour control with fewer side effects. Making adaptive proton therapy practical can improve outcomes for patients across Europe (and beyond) and help healthcare systems deliver high-quality, personalised cancer care more efficiently. RAPTOR had two goals: (1) create the scientific and technical building blocks needed for online (daily or real-time) adaptive particle therapy—covering imaging, planning, and verification—and (2) train a new generation of experts who can bring these methods into clinics and industry. RAPTOR delivered integrated solutions across the full adaptive workflow. The consortium developed novel methods for image segmentation, synthetic CT generation, and dose accumulation; produced optimisation engines and visualisation tools for daily treatment planning and 4D dose reconstruction; and advanced in-vivo verification approaches and phantom-based verification tools to enable safe, adaptive treatment workflows. These components were validated in silico, in phantoms, and—critically—combined into end-to-end tests. A milestone outcome was the first clinical implementation of online adaptive proton therapy at PSI (Switzerland), demonstrating feasibility without extending treatment times. In total, 15 early-stage researchers were trained through accredited schools, secondments, and an open e-learning platform; several have already defended PhDs or moved into clinical and industrial roles. RAPTOR’s results were widely disseminated through publications, conferences, and public-facing videos. Its legacy will continue via the follow-up EU-MSCA-RAPTORplus project, focused on broader clinical uptake and biologically informed adaptation.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The Real-time Adaptive Particle Therapy Of CanceR (RAPTOR) consortium comprises world-class research institutes, non-academic particle therapy (PT) centres and industrial providers of PT equipment, offering a platform for intercultural, interdisciplinary and intersectoral training of early stage researchers (ESRs) in the field of medical physics with a focus on real-time adaptive PT. This comprehensive expertise and infrastructure is required to address and solve challenges in the clinical implementation of real-time adaptive PT.PT is an advanced type of radiotherapy used to treat a constantly rising number of cancer patients. PT allows to target tumour with a high accuracy while sparing healthy surrounding tissue from dose. However, changes in anatomy or positioning and organ motion give rise to uncertainties which need to be further minimized to exploit the full benefits of PT. Adapting PT plans in real time has the potential to provide truly personalized treatments, allowing for better target control and less toxicity. A move towards wide clinical implementation of adaptive PT approaches is currently prohibited by (i) stepwise treatment workflows that are time-consuming and largely manual, (ii) the inflexibility of commercial PT equipment, and (iii) the wide range of PT equipment and protocols.RAPTOR ESRs will conduct research projects at both academic and non-academic health care facilities which will sharpen their focus on clinical needs with respect to real-time adaptive PT. The active involvement of industry ensures that the transfer of industry-relevant skills is an integral part of individual ESR projects. This will guarantee rapid translation of clinical needs into innovative and marketable solutions.RAPTOR aims to train a new generation of researchers, enabling a paradigm shift from treatment approaches that are manual and stepwise to those that are automatic and seamless, while assuring standardized clinical implementation of real-time adaptive PT.

Оригинален текст от CORDIS (на английски).

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Данни: CORDIS, © Европейски съюз