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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Докторантска мрежа2021–2025

EndoConnect · EU Training Network in understanding the molecular regulation and the role of endo-lysosomal processes in cardio-metabolic diseases

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2021-01-01 → 2025-03-31
Финансиране от ЕС
4 050 849 €
Участници
12
Схема
MSCA-ITN

Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.

Накратко на български

Ендо-лизозомната система и нейният контрол върху метаболизма на глюкозата и мазнините са в центъра на вниманието. Разбирането на тези процеси помага да се разбере развитието на сърдечно-метаболитни заболявания и някои видове рак, като например рак на черния дроб.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

EU Training Network in understanding the molecular regulation and the role of endo-lysosomal processes in cardio-metabolic diseases

The EndoConnect consortium successfully generated novel insights into the molecular regulation of the endo-lysosomal system and its involvement in metabolic pathways, including glucose and lipid metabolism. Disruptions in these pathways are known to contribute to cardio-metabolic diseases and elevate the risk of various cancers as liver cancer. These scientific advances were made possible through a highly interdisciplinary approach, bringing together diverse research fields and expertise. The results of the individual ESR projects established a solid scientific foundation for future research and collaboration among the host institutions. These findings not only enhance our understanding of the molecular regulation of the endo-lysosomal system but also enable the consortium to pursue new research initiatives and funding opportunities. Beyond scientific achievements, EndoConnect successfully trained a cohort of highly skilled ESRs, equipping them with the expertise and professional competencies needed to prosper in both academic and industrial settings. The ESRs actively managed their research projects, conducted molecular, cellular, and metabolic experiments, established collaborative networks, and played key roles in organizing a successful final symposium with scientists from different international labs. All ESRs are now well-positioned to defend their PhD theses and take the next step in their careers. Several will continue in academia as postdoctoral researchers, while others will pursue opportunities in the pharmaceutical industry. EndoConnect not only advanced science but also fostered the development of the next generation of leading researchers.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The endo-lysosomal system is essential to acquire lipids and nutrients according to the need of the cell and, subsequently, to maintain metabolic homeostasis. The strong connection between the endo-lysosomal system and metabolism is reflected in the observations that defects in this system are correlated with cardio-metabolic disorders, such as cardiovascular disease, type 2 diabetes and non-alcoholic fatty liver disease. The molecular mechanisms that interconnect the endo-lysosomal system with metabolism are, however, poorly understood. This can be largely explained by the fact that (1) endo-lysosomal and metabolic research are carried out independent of each other and (2) the number of model systems to study endo-lysosomal processes at an organismal and clinical level are limited. It is the ambition of EndoConnect to change this by bringing top scientists and industrial partners together to train early stage researchers in interdisciplinary research, with the focus on translating key findings from cellular and animal models to patients with cardio-metabolic diseases. It is our mission to: (1) understand the molecular organization and regulation of endo-lysosomal processes, (2) elucidate how metabolism and endo-lysosomal processes are intertwined, (3) understand how defects in the endo-lysosomal system contribute to the development of cardio-metabolic diseases and, finally, (4) how the endo-lysosomal system contributes to the efficiency of therapeutics. EndoConnect will provide an international training program for early stage researchers to acquire knowledge and state-of-the-art scientific, technical, and transferable skills to connect molecular and cell biology research with physiology and biomedical research towards translation. We expect that EndoConnect will increase our understanding of the molecular interrelation of the endo-lysosomal system with cardio-metabolic diseases, which will pave the road for novel diagnostics and therapeutics.

Оригинален текст от CORDIS (на английски).

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Данни: CORDIS, © Европейски съюз