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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Обмен на изследователи2021–2026

UNAT · Ultra-small Nanohybrides for Advanced Theranostics

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2021-04-01 → 2026-03-31
Финансиране от ЕС
832 600 €
Участници
5
Схема
MSCA-RISE

Линиите свързват координатора с партньорите.

Накратко на български

Свръхмалки хибридни наночастици от въглерод и метал, създадени от биомаса, се тестват за диагностика и терапия при рак. Тези материали помагат за по-точното визуализиране на туморите чрез различни видове медицинско образяване.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Ultra-small Nanohybrides for Advanced Theranostics

For some time now, research focusing on the application of nanomaterials in different areas has become a key driver of innovation. Such innovative material are even used in medicine and are progressively making their entrance in the hospital where they are being used for diagnostic and for therapy. The UNAT project is in this line and aims at a systematic interdisciplinary study of metal-carbon nanohybrides (NHs) for possible advanced theranostic applications. Indeed, the development of NHs based on organic & inorganic moieties can synergistically or antagonistically influence functional properties of engineered nanotheranostic drugs. UNAT will develop innovative approaches to syntheses and multi-functional application of ultra-small (<10 nm) carbon-based NHs functionalized with various metal atoms for diagnostics and therapy in the filed of oncology. In particular, carbon cores of NHs will be chemically synthesized from biomasses and/or bio-wastes. The combination of pre-clinical in-vitro & in-vivo experiments will allow us to evaluate the theranostic potential of the NHs. the UNAT project will associate an industrial partner from Greece (Bioemtech), an industrial partner from France (GLINCS), a research and innovation center from Ukraine (Science Park) and 2 academic research groups from France (UCBL) and Italy (CNR) respectively. The uptake efficiency and localization of NHs in cells, influenced by their surface chemistry, will be detailed. Their rich physico-chemical properties enable their use as universal multi-modal (MRI, PET, X-ray, Fluorescence, Photoacoustic) in-vivo bio-imaging agents. This multimodal strategy improves visualization reliability of NHs in tumors. Various exciting electro-magnetic sources used for medical purposes will be simultaneously used for therapy of cancer tissues containing the incorporated NHs. The strong complementary beetween the different research experiences of the partners involved in the project and a high degree of cooperative integration between them will allow a extensive and serious study of the theranostic potential of the NHs.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Nowadays, research focusing on control and use of nanomaterials in different areas including life sciences has become a key driver of innovation. UNAT project aims at a systematic interdisciplinary study of metal-carbon nanohybrides (NHs) for advanced theranostic application. Indeed, development of NHs based on organic & inorganic moieties can synergistically or antagonistically influence functional properties of engineered nanotheranostic medicines. UNAT will develop innovative approaches for synthesis and multi-functional application of ultra-small (<10 nm) carbon-based NHs functionalized with various metal atoms for diagnostics and therapy of cancer. In particular, carbon cores of NHs will be chemically synthesized from biomasses and bio-wastes. The combination of pre-clinical in-vitro & in-vivo experiments will allow to evaluate theranostic potential of the NHs.UNAT will associate an industrial partner from Greece (Bioemtech), a research and innovation center from Ukraine (Science Park) and 2 academic research groups from France (UCBL) and Italy (CNR). The uptake efficiency and specific localization of the NHs in biological cells depending on their intentionally designed surface chemistry will be studied in details. Extremely rich physico-chemical properties of the NHs will allow their application as universal multi-modal (MRI, PET, X-ray, Fluorescence, Photoacoustic) in-vivo bio-imaging agents. The multimodal imaging strategy will allow us to correlate the images obtained with the use of various imaging facilities to increase general reliability of visualization of the NHs localization in tumours. Various exciting electro-magnetic sources used for medical purposes will be simultaneously used for therapy of cancer tissues containing the incorporated NHs. Strongly complementary research experiences of the partners involved in UNAT and a high degree of cooperative integration between them will allow a deep scientific study of the theranostic potential of the NHs.

Оригинален текст от CORDIS (на английски).

Участници

Връзки

Данни: CORDIS, © Европейски съюз