PERFHeart · Development of three dimensional coronary blood perfusion model in beating heart using advanced computational and experimental techniques.
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2021-02-01 → 2023-01-31
- Финансиране от ЕС
- 196 591 €
- Участници
- 1
- Схема
- MSCA-IF
Линиите свързват координатора с партньорите.
Накратко на български
Кръвното снабдяване на сърдечния мускул се анализира чрез създаване на 3D модел на работещото сърце. Това помага да се разбере как недостигът на кръв води до увреждане на клетките и сърдечна недостатъчност.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Development of three dimensional coronary blood perfusion model in beating heart using advanced computational and experimental techniques.
Despite dramatic medical advances over the last few decades, CVD remain a leading cause of death globally and the number one cause of death in the European Union (EU).While present day finite element(FE)models compute stress and strain in the heart muscle,they donot compute the regional blood perfusion and therefore missthe key factor that may lead to cell necrosis and failure of the heart. Coronary vascular disease has been studied for many decades and has been found to be a complexproblem. Despite the tedious and creative work by many expert scientists from many differentperspectives, the disease has only partially been understood. The current state of the art in cardiac FE modelling provides the capability to compute myocardial stresses and strains and has led to successful commercialisation of the code for simulation of the ability of cardiac devices to improve the performance ofthe heart in different pathologies. Despite the importance of coronary vascular perfusion, FEmodelling of cardiac tissue has greatly overlooked "perfusion"as a key component of cardiac health. The objectives of the study is to explore the role ofcoronary perfusion in cardiac health by developing simulation of cardiac cycle using experimental and computational modelling
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Coronary vascular disease(CVD) has been studied for many decades and has been found to be a very complex problem.Despite dramatic medical advances over the last few decades, CVD remain a leading cause of death globally and thenumber one cause of death in the European Union (EU). Inspite of the tedious and creative work by many expert scientistsfrom many different perspectives, the disease has only partially been understood. The approach that is taken here differs inbasic tenets from earlier approaches, in that it starts from a very basic system of study inorder to progressively build higherlevels of complexity. It is understood that the vast majority of the life threatening pathologies are associated with animbalance between the demand in oxygen and the supply provided by the RBCs. This project will start studying the structureof the microvascular geometry and upscale the coronary circulation from there. The microvascular bed will be embedded intoa beating heart with all complexities associated with it:contracting muscle fibre, complex fibre architecture, valves, coronaryarteries and veins, etc. On that level, the project will multi-stage and multiscale with finite element (FE) modelling ofmyocardial contraction, deformation and perfusion. The interdisciplinary perspective in this study is strong with contributionsfrom engineers, clinicians and biomaterial scientists. The scope of the study is usage of FE modelling for autoregulation ofcoronary perfusion which extends the applications of FE model to common pathologies such as ischemic heart disease,infarction or reperfusion issues and devices such as stents or cardiac assist devices, that improve coronary blood perfusion.This project is in line with the European heart health charter to promote research in the field of cardiovascular diseases.
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITY OF LIMERICK · LimerickКоординаторИрландия
Връзки
Данни: CORDIS, © Европейски съюз