H2020Индивидуална стипендия2021–2023

TWSCC · Trafficking of Wnt Signaling Components in Cancer

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-09-01 → 2023-08-31
Финансиране от ЕС: 162 806 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Механизмите за транспорт на протеини в мембраната на клетките се изследват, за да се разбере как мутации в гена Apc активират рака на дебелото черво. Това е важно за разработването на нови терапии, които да удължат живота на пациентите.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Trafficking of Wnt Signaling Components in Cancer

Colorectal cancer (CRC) is a leading cause of cancer related deaths throughout the world. Inactivating mutations to the tumour suppressor gene Adenomatous polyposis coli (Apc) are considered to be an early event that initiates this disease in approx. 80% of cases. Apc is a component of the Wnt signalling pathway and has several roles including inhibiting β-catenin, which functions as a transcriptional coactivator in the nucleus and is a component of the adherens junction. The loss of Apc function constitutively activates Wnt signalling to drive proliferation and provide cells with a competitive advantage over their surrounding wild type cells, which initiates tumour formation. Over the past three decades we have gained a good understanding of the mutations that are involved in the progression of this disease. However, we currently lack insight into the membrane trafficking mechanisms that are involved in modulating dysregulated Wnt signalling. Current efforts at developing effective therapies for CRC have had limited success. Therefore, there is an urgent need to develop novel therapeutics that can extend patient life, especially during late stage CRC. Discovering such therapies will have a significant positive impact on society since CRC is currently a major health burden, costing the EU approx. €19.1 billion per year. The overall objective of this proposal is to directly address what roles membrane trafficking events have in modulating dysregulated Wnt signalling. We aim to 1) identify novel trafficking regulators that are involved in Wnt signalling when Apc is mutated, 2) discover the mechanisms that are involved in modulating Wnt signalling, 3) perform translation experiments to understand the conservation of mechanisms involved.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The Wnt cascade is an evolutionary conserved pathway that controls cell proliferation, differentiation and growth. Although mutations to this pathway are commonly associated with certain cancers (e.g. colorectal/breast cancer), other mechanisms that control Wnt activity, e.g. its intracellular trafficking regulation, has not received significant attention in the past. The objective of this fellowship is to use my existing knowledge of cell biology to map the trafficking routes that Wnt components take in normal cells, and to test if these routes are altered in cancers to sustain their proliferative capacity. This project will combine bioinformatic analysis to find lead candidates to further investigate in the model organism Drosophila melanogaster. By generating novel fly strains and using high-resolution imaging, I aim to advance our understanding on how Wnt components are trafficked in vivo.

Оригинален текст от CORDIS (на английски).

Участници

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG · HeidelbergКоординаторГермания