H2020Индивидуална стипендия2021–2023

PROGRAMED PROTOCELLS · Design and construction of programmed protocells for intercellular networks and biomimetic communications

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-08-01 → 2023-07-31
Финансиране от ЕС: 224 934 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Синтетичните протоклетки се конструират така, че да разпознават химични сигнали и да работят заедно като живи общности. Това помага да се разбере как животът е възникнал от неживи химични съединения и каква е ролята на химията в еволюцията.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Design and construction of programmed protocells for intercellular networks and biomimetic communications

The project “Programmable protocells for selective intercellular interactions and biomimetic communications” studies how synthetic cells or protocells can be constructed with an aim to produce specific functions or outputs. The current simplistic designs to build artificial cells limits their structural and organizational complexity and in turn their potential in applications. Employing concepts of bottom-up technology for the defined design and construction of complex synthetic constructs to generate programmable communities of protocells with the ability to sense, categorize, and process chemical signals collectively opens avenues to building life-like materials. The intention behind the construction of these cell-like mimics is to understand the origin of life from non-living constituents and bridge the gap between chemistry and biology. The motivation for this project comes from understanding Nature. This field is of utmost importance for understanding the process behind evolution and the role chemistry plays in it. Objectives of this Marie Skłodowska Curie Action (MSCA) is are) to design, develop, and construct self-organized protocellular communities that encapsulate intricate enzymatic reaction networks and capable of spontaneous and cooperative operation, akin to living cells behaviour, (ii) incorporating several essential functions within these protocellular communities such as the selective formation of protocellular consortia and mimicking critical biological functions, thereby enhancing the complexity of the protocellular constructs achieving proto-colonies, (iii) applying the principles of organic synthesis, supramolecular chemistry and out-of-equilibrium self-assembly to the interdisciplinary and evolving field of protocells. Ultimately, these research efforts intend to realize programmable protocells capable of active self-assembly, spatiotemporal self-sorting, self-regulation and higher-order organization and function. Overall, the aim is to push the boundaries of chemistry to understand and mimic biology. In parallel, the goal of the MSCA Individual Fellowship is to foster the personal growth and scientific independence of the Fellow (me).

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Artificial cellular counterparts (protocells) can be fabricated to produce explicit biomimetic outcomes such as RNA-mediated replication, gene expression, metabolism, etc. These synthetic mimics with cell-like traits, aim to answer fundamental questions regarding origin of cellularity from non-living components. However, minimal levels of structural/organisational complexity exhibited in current protocell designs, limits their application potential. The aim of this proposal is to use bottom-up approaches to precisely design and construct complex protocells through membrane coupled appendages and produce interactive protocellular communities which will recognize, sort and processes chemical signals through collective behaviour. The self-assembled protocellular colonies will be sequestered with complex enzymatic reaction networks which operate spontaneously and synergistically reminiscent to living cells. Several important functions such as selective formation of protocellular consortia, mimicking important biological functions such as IDH-kinase/phosphatase (AceK) circuitry from the Krebs cycle, redox-homeostasis, self-protection from chemical degradation will increase the complexity of the protocellular constructs producing the first example of functional proto-colonies. The expertise of the applicant in the field of organic synthesis, supramolecular chemistry and out-of-equilibrium self-assembly will be employed by the multidisciplinary and evolving field of protocells pioneered by the hosting group of Professor Stephen Mann FRS at the University of Bristol. The combined research efforts of the applicant and the Mann group will result in the successful realization of programmable protocells resulting in active self-assembling protocellular constructs and build their advanced forms capable of spatio-temporal self-sorting, self-regulation and higher-order organization and function.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITY OF BRISTOL · BRISTOLКоординаторОбединеното кралство