UkrAD · Adaptation and Demographic Processes in Ukraine from the Mesolithic to the Present
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2021-06-01 → 2023-05-31
- Финансиране от ЕС
- 212 934 €
- Участници
- 1
- Схема
- MSCA-IF
Линиите свързват координатора с партньорите.
Накратко на български
Генетичният състав на хората в Украйна от неолита до средновековието се анализира чрез древна ДНК, за да се проследят миграции на групи като скитите и монголите. Това помага да се разбере как миграциите и средата са оформили съвременните общества и човешкия геном.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Adaptation and Demographic Processes in Ukraine from the Mesolithic to the Present
Migration, admixture and natural selection have been a major factors shaping human societies and genomes through time. Ancient DNA research indicates that, by-and-large, the genomes of present-day Europeans comprise ancestries from three major layers of people: local hunter-gatherers, Near Eastern early farmers, Steppe pastoralists. However, the detailed genetic history of any given area is always much more complex, calling for more focused and local-scale studies. One such relatively understudied region is present-day Ukraine. Southern Ukraine, as part of the Eurasian Steppe, has been in the path of several migrating groups, e.g. Yamnaya Steppe pastoralists, mixed-origin Cimmerians and Scythians, Gothic Chernyakhov people, Iranian Alans, Golden Horde Mongols, Turkic Nogais, Slavic Cossacks. It is important to study demographic history to gain insight into migrations and admixture events in the past to help us understand how these processes have shaped genomes and societies and influenced how today's populations have come to be. Also, tracing the drivers of natural selection in the past can shed light on how changes in the environment (both natural and societal) have led to phenotypic changes in humans which in turn can provide clues for how we might respond to the changing environment in the future. The main research objectives of the project were to generate genomic data from individuals from the Neolithic to the Middle Ages in order to shed light on patterns of genetic variation in Ukraine through time, to characterize the composition of their ancestries and interpret the results in the context of archaeological and historical information in order to understand the demographic history of the area, and to compare hypothesized ecological drivers of selection using a range of ecological proxies in a likelihood framework in order to pinpoint the drivers of selection. Futhermore, the objective of this project is for the researcher to mature to be independent by developing excisting and acquiring new skills – furthering her skills in her current research area of demographic history inference and expanding into a new field of studying natural selection, as well as developing transferable skills by conceiving and managing a project, disseminating and communicating the project results, networking, and supervising students. The main research conclusion of the project is that there has been a lot of genetic variability in Ukraine through time, especially during the Iron Age and the Middle Ages. What is more, the researcher has developed and acquired skills both directly related to research as well as transferable skills and has matured into an independent scientist who is ready to apply for further funding and conduct high-quality research as a principal investigator.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Migration, admixture and natural selection have been shaping human societies and genomes through time. Southern Ukraine, as part of the Eurasian Steppe, has been in the path of several migrating groups, e.g. Yamnaya Steppe pastoralists, mixed-origin Cimmerians and Scythians, Gothic Chernyakhov people, Iranian Alans, Golden Horde Mongols, Turkic Nogais, Slavic Cossacks. This fellowship aims to study how one of the main ancestry components in Europe, the fusion of Steppe and early farmer ancestry, formed and how other migration processes shaped genetic variation in Ukraine. Furthermore, we aim to identify important signals of selection (e.g., diet- and immunity-related) and their ecological drivers. To that end, genomic data of 150 individuals will be generated. The ancestry composition of the individuals will be characterized in the context of modern and ancient samples, and interpreted in the context of archaeological and historical information. A novel likelihood-based method will be used to test hypotheses of which ecological factors, such as urbanization, higher population density, mobility, zoonoses, famine and wider contact networks, have been important in driving selection on alleles related to infectious disease resistance, through influencing sanitation and pathogen transmission. The researcher will mature to be independent thanks to developing excisting and acquiring new skills through training received from the host and the secondment host. She will further her skills in her current research area of demographic history inference and will expand into a new field – studying natural selection. Furthermore, she will develop transferable skills by conceiving and managing a project, disseminating the project results through journal articles, conference presentations etc., communicating scientific results to students, science enthusiasts and the general public, networking with people from the host/secondment team and external collaborators, supervising students.
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITY COLLEGE LONDON · LondonКоординаторОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз
